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Tangeretin mitigates l-NAME-induced ventricular dysfunction and remodeling through the AT1R/pERK1/2/pJNK signaling pathway in rats.
Food & Function ( IF 5.1 ) Pub Date : 2020-02-07 , DOI: 10.1039/c9fo02365h Chutamas Wunpathe 1 , Putcharawipa Maneesai , Siwayu Rattanakanokchai , Sarawoot Bunbupha , Upa Kukongviriyapan , Terdthai Tong-Un , Poungrat Pakdeechote
Food & Function ( IF 5.1 ) Pub Date : 2020-02-07 , DOI: 10.1039/c9fo02365h Chutamas Wunpathe 1 , Putcharawipa Maneesai , Siwayu Rattanakanokchai , Sarawoot Bunbupha , Upa Kukongviriyapan , Terdthai Tong-Un , Poungrat Pakdeechote
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Tangeretin is a citrus flavonoid that exerts several beneficial effects, including anti-inflammation, anti-oxidation and neuroprotection. In this study, the aim was to test the effect of tangeretin on Nω-Nitro-l-arginine methyl ester (l-NAME)-induced high blood pressure, and left ventricular dysfunction and remodeling in rats. Rats were divided into five groups (n = 8 per each group): a control group, an l-NAME group and three l-NAME groups treated with tangeretin (15 mg kg-1) or tangeretin (30 mg kg-1) or captopril (5 mg kg-1) for the final two weeks. After five weeks of experiment, l-NAME groups had high systolic blood pressures, and ventricular dysfunction and remodeling. Overexpression of angiotensin II type 1 receptor, phosphorylated-extracellular-regulated kinase 1/2 (pERK1/2), and phosphorylated-c-Jun N-terminal kinase (pJNK) protein but downregulation of endothelial nitric oxide synthase (eNOS) protein expression in ventricular tissues were observed in hypertensive rats while the protein expression of phosphorylated-mitogen activated protein kinase p38 did not differ among groups. The decrease in plasma NOx and increase in vascular superoxide generation, plasma malondialdehyde, angiotensin-converting enzyme activity and angiotensin II levels were found in hypertensive rats. These alterations were suppressed in hypertensive rats treated with tangeretin or captopril. In conclusion, tangeretin exhibits antihypertensive effects and alleviates ventricular dysfunction and remodeling in hypertensive rats. These effects are associated with the inhibition of renin angiotensin system activation and restoration of pERK1/2, pJNK, and eNOS protein expressions along with reduced oxidative stress and increased NO bioavailability.
中文翻译：
橘皮苷通过大鼠的AT1R / pERK1 / 2 / pJNK信号通路减轻l-NAME引起的心室功能障碍和重塑。
橘子是一种柑橘类黄酮，具有多种有益作用，包括抗炎，抗氧化和神经保护作用。在这项研究中，目的是测试橘皮素对大鼠Nω-硝基-1-精氨酸甲酯（l-NAME）诱发的高血压以及左心室功能障碍和重塑的影响。将大鼠分为五组（每组n = 8）：对照组，l-NAME组和三个以坦格列汀（15 mg kg-1）或坦格列汀（30 mg kg-1）或最后两周服用卡托普利（5 mg kg-1）。经过五周的实验，l-NAME组的收缩压较高，并且出现心室功能障碍和重塑。1型血管紧张素II受体过表达，磷酸化细胞外调节激酶1/2（pERK1 / 2），和磷酸化的c-Jun N末端激酶（pJNK）蛋白，但在高血压大鼠的心室组织中观察到内皮型一氧化氮合酶（eNOS）蛋白表达下调，而磷酸化促分裂原活化蛋白激酶p38的蛋白表达没有差异组。在高血压大鼠中发现血浆NOx减少和血管超氧化物生成，血浆丙二醛，血管紧张素转化酶活性和血管紧张素II水平增加。在用橘皮苷或卡托普利治疗的高血压大鼠中，这些改变被抑制。综上所述，橘皮苷具有抗高血压作用，可减轻高血压大鼠的心室功能障碍和重塑。这些作用与抑制肾素血管紧张素系统的活化以及pERK1 / 2，pJNK，
更新日期：2020-02-26
中文翻译：
橘皮苷通过大鼠的AT1R / pERK1 / 2 / pJNK信号通路减轻l-NAME引起的心室功能障碍和重塑。
橘子是一种柑橘类黄酮，具有多种有益作用，包括抗炎，抗氧化和神经保护作用。在这项研究中，目的是测试橘皮素对大鼠Nω-硝基-1-精氨酸甲酯（l-NAME）诱发的高血压以及左心室功能障碍和重塑的影响。将大鼠分为五组（每组n = 8）：对照组，l-NAME组和三个以坦格列汀（15 mg kg-1）或坦格列汀（30 mg kg-1）或最后两周服用卡托普利（5 mg kg-1）。经过五周的实验，l-NAME组的收缩压较高，并且出现心室功能障碍和重塑。1型血管紧张素II受体过表达，磷酸化细胞外调节激酶1/2（pERK1 / 2），和磷酸化的c-Jun N末端激酶（pJNK）蛋白，但在高血压大鼠的心室组织中观察到内皮型一氧化氮合酶（eNOS）蛋白表达下调，而磷酸化促分裂原活化蛋白激酶p38的蛋白表达没有差异组。在高血压大鼠中发现血浆NOx减少和血管超氧化物生成，血浆丙二醛，血管紧张素转化酶活性和血管紧张素II水平增加。在用橘皮苷或卡托普利治疗的高血压大鼠中，这些改变被抑制。综上所述，橘皮苷具有抗高血压作用，可减轻高血压大鼠的心室功能障碍和重塑。这些作用与抑制肾素血管紧张素系统的活化以及pERK1 / 2，pJNK，
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