Abstract In this study, poly (e‐caprolactone) (PCL) scaffolds were printed and reinforced, simultaneously, with biodegradable poly glycolic acid (PGA) suture yarn, as a continuous reinforcing fiber, in the Fused Deposition Modeling (FDM) 3D printing process. Albeit PCL is a suitable material for biomedical applications, its low mechanical properties, and low degradation rate have limited its usage. A biocompatible suture yarn was used as the reinforcing material to enhance the mechanical properties and biodegradation characteristics, via an innovative method of continuous fiber embedding in the FDM process. The reinforced PCL samples were 3D printed with the setting porosity value of 60% and 0°/60°/120° lay-down pattern. The mechanical and biological properties of the scaffolds were tested to prove the effectiveness of the produced scaffolds for bone substitute purposes. Mechanical properties assessments showed that with a 22 vol.% suture yarn content in the 3D printed PCL scaffolds, the tensile strength, and elastic modulus remarkably increased up to 374% and 775%, respectively. The degradation of the reinforced PCL was 20 times higher than that of the non-reinforced PCL samples, after ten weeks, dominated by the fiber degradation phenomenon. After three days of cell culture, the proliferation assay of the built scaffovd the non-toxicity of the reinforced PCL.

中文翻译：

---

用连续可生物降解纤维纱增强的 3D 打印 PCL 支架：机械和细胞活力特性的研究

摘要 在这项研究中，聚（e-己内酯）（PCL）支架被打印和增强，同时使用可生物降解的聚乙醇酸（PGA）缝合线作为连续增强纤维，在熔融沉积建模（FDM）3D打印过程中. 尽管 PCL 是一种适用于生物医学应用的材料，但其低机械性能和低降解率限制了其使用。通过在 FDM 过程中连续纤维嵌入的创新方法，使用生物相容性缝合线作为增强材料，以增强机械性能和生物降解特性。增强型 PCL 样品采用 60% 的设定孔隙率值和 0°/60°/120° 铺设图案进行 3D 打印。测试支架的机械和生物学特性以证明所生产的支架用于骨替代目的的有效性。机械性能评估表明，3D 打印 PCL 支架中的缝合线含量为 22 vol.%，拉伸强度和弹性模量分别显着增加至 374% 和 775%。十周后，增强型 PCL 的降解率比非增强型 PCL 样品的降解率高 20 倍，主要是纤维降解现象。细胞培养三天后，构建的支架的增殖试验证实了增强型 PCL 的无毒。和弹性模量分别显着增加至 374% 和 775%。十周后，增强型 PCL 的降解率比非增强型 PCL 样品的降解率高 20 倍，主要是纤维降解现象。细胞培养三天后，构建的支架的增殖试验证实了增强型 PCL 的无毒。和弹性模量分别显着增加至 374% 和 775%。十周后，增强型 PCL 的降解率比非增强型 PCL 样品的降解率高 20 倍，主要是纤维降解现象。细胞培养三天后，构建的支架的增殖试验证实了增强型 PCL 的无毒。