Abstract Novel Schiff base (L) derived from 6-aminobenzothiazole and 4-methoxy salicylaldehyde and its bivalent Cu(II) (1), Ni(II) (2) and Co(II) (3) metal complexes were synthesized and thoroughly characterized by various analytical and spectral techniques. From the data a square planar geometry is assigned for all complexes. The DNA interaction studies of complexes with CT-DNA were carried out by UV–Vis absorption, fluorescence and viscosity measurements. These studies revealed that the complexes bind to CT-DNA by intercalative mode. DNA cleavage capacity of all the metal complexes was studied by agarose gel electrophoresis method. Further, the antibacterial studies of metal complexes were evaluated and it is observed that all complexes showed grater activity than free ligand. In addition, in-vitro cytotoxicity of these complexes on tumor cell lines HeLa, A549 and MCF-7 have been examined by MTT assay. The complexes showed greater cytotoxicity than the free Schiff base ligand.

中文翻译：

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6-氨基苯并噻唑席夫碱二价过渡金属配合物的合成、结构表征、DNA相互作用、抗菌和细胞毒性研究

摘要 合成了源自 6-氨基苯并噻唑和 4-甲氧基水杨醛的新型席夫碱 (L) 及其二价 Cu(II) (1)、Ni(II) (2) 和 Co(II) (3) 金属配合物，并对其进行了全面表征。通过各种分析和光谱技术。根据数据，为所有复合体分配了方形平面几何形状。复合物与 CT-DNA 的 DNA 相互作用研究通过 UV-Vis 吸收、荧光和粘度测量进行。这些研究表明复合物通过嵌入模式与 CT-DNA 结合。通过琼脂糖凝胶电泳法研究了所有金属配合物的DNA裂解能力。此外，对金属配合物的抗菌研究进行了评估，观察到所有配合物都显示出比游离配体更高的活性。此外，这些复合物对肿瘤细胞系 HeLa、A549 和 MCF-7 的体外细胞毒性已通过 MTT 测定进行了检查。复合物显示出比游离希夫碱配体更大的细胞毒性。