Effects of bleomycin on tooth eruption: a novel potential application.,European Journal of Pharmaceutical Sciences

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Effects of bleomycin on tooth eruption: a novel potential application.
European Journal of Pharmaceutical Sciences ( IF 4.3 ) Pub Date : 2020-01-11 , DOI: 10.1016/j.ejps.2020.105214
Hai-Tao Wang ₁ , Jing-Nan Wang ₁ , Zhi-Zheng Li ₁ , Hou-Fu Xia ₁ , Chao-Fan Wang ₁ , Yu Cai ₂ , Yi-Fang Zhao ₂ , Jian-Gang Ren ₂ , Ji-Hong Zhao ₂

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There are many kinds of potentially undesirable teeth. At present, surgical extraction is the most efficient way to eliminate these teeth, but it's very complex and invasive. In this study, we investigated the effects of bleomycin (BLM) on dental follicle and tooth eruption as a potential conservative therapy for undesirable teeth. Our data showed that local injection of 0.2 U/kg BLM had no significant effects on tooth eruption compared to the control group in Wistar rats. With higher dose of BLM (0.5 or 2 U/kg), the eruption of treated teeth was interrupted and their root formation failed until 4 weeks postnatal without significant systemic toxicity. Additionally, those effects were not depending on the toxicity of overdose evidenced by TUNEL assay. In summary, injecting BLM into dental follicle at an early stage could interrupt tooth development and eruption, and may prevent the potentially clinical problems resulting from undesirable teeth instead of surgical removal.

中文翻译：

博来霉素对牙齿萌发的影响：一种新型的潜在应用。

有许多潜在的不良牙齿。目前，手术拔除是消除这些牙齿的最有效方法，但它非常复杂且具有侵入性。在这项研究中，我们调查了博来霉素（BLM）对牙囊和牙齿萌出的影响，作为对不良牙齿的潜在保守疗法。我们的数据表明，与Wistar大鼠的对照组相比，局部注射0.2 U / kg BLM对牙齿萌发没有明显影响。使用较高剂量的BLM（0.5或2 U / kg），治疗后的牙齿萌发被中断，并且其牙根形成失败，直到出生后4周没有明显的全身毒性。此外，这些影响不取决于TUNEL分析所证明的过量用药的毒性。综上所述，

更新日期：2020-01-13

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