Therapeutic resistance is a major challenge in cancer treatment. In this issue of Cancer Cell, Kurppa et al. demonstrated that a senescence-like state enables lung cancer cells to survive dual inhibition of EGFR and MEK. This was mediated by the YAP/TEAD pathway, which drives epigenomic reprogramming and EMT to counteract apoptosis.

中文翻译：

---

生存的感觉：YAP介导的休眠逃脱了EGFR / MEK抑制作用。

治疗抗性是癌症治疗中的主要挑战。在本期《癌细胞》中，Kurppa等人。证明衰老样状态使肺癌细胞能够幸免于EGF​​R和MEK的双重抑制。这是由YAP / TEAD途径介导的，该途径驱动表观基因组重编程和EMT以抵消细胞凋亡。