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Cancer Genome Evolutionary Trajectories in Metastasis.
Cancer Cell ( IF 48.8 ) Pub Date : 2020-01-13 , DOI: 10.1016/j.ccell.2019.12.004
Nicolai J Birkbak 1 , Nicholas McGranahan 2
Affiliation  

Metastatic cancer is a major cause of death and remains largely incurable. A better understanding of metastasis is therefore desperately needed to improve prognosis for late-stage disease. Here we survey the landscape of studies exploring the genomics of metastatic cancer. We consider evidence for genomic drivers of metastasis and explore studies investigating modes of metastatic spread.

中文翻译:


转移中的癌症基因组进化轨迹。



转移性癌症是死亡的主要原因,并且在很大程度上仍然无法治愈。因此,迫切需要更好地了解转移,以改善晚期疾病的预后。在这里,我们调查了探索转移性癌症基因组学的研究概况。我们考虑转移基因组驱动因素的证据,并探索研究转移扩散模式的研究。
更新日期:2020-01-13
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