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Oncostatin M Is a Prognostic Biomarker and Inflammatory Mediator for Sepsis.
The Journal of Infectious Diseases ( IF 6.4 ) Pub Date : 2020-01-13 , DOI: 10.1093/infdis/jiaa009
Yi Gong 1 , Xingxing Yan 2 , Xiaomin Sun 3 , Tangtian Chen 2 , Yi Liu 4 , Ju Cao 2
Affiliation  

BACKGROUND Oncostatin-M (OSM) is a pleiotropic cytokine of the IL-6 family. The role of OSM in sepsis remains unknown. METHODS Serum OSM level was determined and analyzed in septic patients on day of intensive care unit (ICU) admission. Furthermore, the effects of OSM on polymicrobial sepsis induced by cecal ligation and puncture (CLP) were assessed. RESULTS On day of ICU admission, septic patients had significantly higher serum OSM levels when compared with ICU patient controls and healthy volunteers, which were related to the severity of sepsis, including parameters such as the Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score, procalcitonin (PCT) level, and white blood cell (WBC) number. A high serum OSM level on ICU admission was associated with 28-day mortality in septic patients. In CLP-induced polymicrobial sepsis, anti-OSM antibody decreased tissue inflammation and injury, and thus improved survival, while local and systemic bacterial dissemination was almost constant. Complementarily, supplementation with recombinant OSM protein in septic mice increased tissue injury, amplified inflammation, and worsened mortality after CLP, while it did not affect bacterial dissemination in septic mice. CONCLUSIONS Sepsis results in an increased production of OSM, which might be a potential prognostic biomarker and therapeutic target for sepsis.

中文翻译:

Oncostatin M是脓毒症的预后生物标志物和炎症介质。

背景技术抑癌素-M(OSM)是IL-6家族的多效细胞因子。OSM在败血症中的作用仍然未知。方法确定重症监护病房(ICU)入院当天败血症患者的血清OSM水平并进行分析。此外,评估了OSM对盲肠结扎和穿刺(CLP)诱导的细菌性败血症的影响。结果在ICU入院当天,败血症患者的血清OSM水平明显高于ICU患者对照和健康志愿者,这与败血症的严重程度有关,包括诸如[与脓毒症相关的]器官衰竭序贯评估(SOFA)等参数)得分,降钙素原(PCT)水平和白细胞(WBC)数量。ICU入院时血清OSM水平高与败血症患者28天死亡率有关。在CLP诱发的败血症中,抗OSM抗体可减少组织炎症和损伤,从而提高生存率,而局部和全身细菌的传播几乎是恒定的。补充地,在败血症小鼠中补充重组OSM蛋白会增加组织损伤,加剧炎症,并增加CLP后的死亡率,但不影响败血症小鼠中细菌的传播。结论脓毒症导致OSM产量增加,这可能是脓毒症的潜在预后生物标志物和治疗靶标。虽然它不影响败血症小鼠中细菌的传播。结论脓毒症导致OSM产量增加,这可能是脓毒症的潜在预后生物标志物和治疗靶标。虽然它不影响败血症小鼠中细菌的传播。结论脓毒症导致OSM产量增加,这可能是脓毒症的潜在预后生物标志物和治疗靶标。
更新日期:2020-01-13
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