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Are Advances in Survival among the Oldest Old Seen across the Spectrum of Health and Functioning?
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences ( IF 5.1 ) Pub Date : 2020-01-13 , DOI: 10.1093/gerona/glaa009
Mikael Thinggaard 1 , Bernard Jeune 1 , Merete Osler 2 , James W Vaupel 3 , Matt McGue 1, 4 , Kaare Christensen 1, 5
Affiliation  

BACKGROUND Mortality rates have been reduced by half over the last 60 years for nonagenarians, and the progress is continuing. The greater survival might be due to overtreatment of severely physically and cognitively disabled individuals which is a big concern for societies and individuals. METHODS The study population comprised two Danish birth cohorts: the 1905 Cohort and the 1915 Cohort. At age 95, all from the two cohorts who were still alive and living in Denmark were invited to participate in a health survey that used the same assessment instrument. A total of 2,670 (56.8%) persons participated in the two surveys and survival was assessed through a 7.3-year follow-up period during which 2,497 (93.5%) had died, and with virtually no loss to follow-up. RESULTS Despite the increasing chance of surviving to age 95, the 1915 Cohort had significantly better health and functioning than the 1905 Cohort. The survival advantage in the 1915 Cohort continued in the follow-up period after age 95: Median survival length was 2.4 months longer, P-value=0.011. This advantage was not statistically associated with different levels of activities of daily living, physical performance, cognitive functioning, self-rated health and life satisfaction. However, the advantage tended to be more pronounced among people with better health. CONCLUSIONS Lifespan and health increases among the oldest old. The improvement in survival for 95-year-olds born in 1915 compared to 1905 was seen across the whole spectrum of health and functioning, with a tendency towards bigger improvement among those in good health.

中文翻译:

在健康和功能谱系中,最古老的老年人的生存状况是否得到改善?

背景技术在过去的60年中,非高加纳人的死亡率已经降低了一半,并且这种进步还在继续。更大的生存率可能是由于严重肢体和认知残疾的个体受到过度治疗而引起的,这是社会和个人的重大关切。方法研究人群包括两个丹麦出生队列:1905年队列和1915年队列。在95岁时,两个仍在丹麦生活并居住在丹麦的队列中的所有人都被邀请参加使用相同评估工具的健康调查。共有2670名(56.8%)的人参加了两次调查,并通过7.3年的随访评估了存活率,在此期间有2497人(93.5%)死亡,并且随访几乎没有损失。结果尽管存活到95岁的机会越来越多,1915年队列的健康和功能要比1905年队列好得多。1915年队列研究的生存优势持续到95岁以后的随访期:中位生存期延长了2.4个月,P值= 0.011。从统计学上讲,这一优势与日常生活,身体表现,认知功能,自我评价的健康和生活满意度的不同水平无关。但是,在健康状况较好的人群中,优势往往更为明显。结论寿命和健康状况在最老的老年人中增加。从1915年出生的95岁婴儿的生存状况来看,与1905年相比,在整个健康和功能方面都有所改善,在健康状况良好的人群中,有更大的改善趋势。1915年队列的生存优势持续到95岁以后的随访期:中位生存期延长了2.4个月,P值= 0.011。从统计学上讲,这一优势与日常生活,身体表现,认知功能,自我评价的健康和生活满意度的不同水平无关。但是,在健康状况较好的人群中,优势往往更为明显。结论寿命和健康状况在最老的老年人中增加。从1915年出生的95岁婴儿的生存状况来看,与1905年相比,在整个健康和功能方面都有所改善,在健康状况良好的人群中,有更大的改善趋势。1915年队列的生存优势持续到95岁以后的随访期:中位生存期延长了2.4个月,P值= 0.011。从统计学上讲,这种优势与日常生活,身体表现,认知功能,自我评价的健康和生活满意度的不同水平无关。但是,在健康状况较好的人群中,优势往往更为明显。结论寿命和健康状况在最老的老年人中增加。从1915年出生的95岁婴儿的生存状况来看,与1905年相比,在整个健康和功能方面都有所改善,在健康状况良好的人群中,有更大的改善趋势。从统计学上讲,这一优势与日常生活,身体表现,认知功能,自我评价的健康和生活满意度的不同水平无关。但是,在健康状况较好的人群中,优势往往更为明显。结论寿命和健康状况在最老的老年人中增加。从1915年出生的95岁婴儿的生存状况来看,与1905年相比,在整个健康和功能方面都有所改善,在健康状况良好的人群中,有更大的改善趋势。从统计学上讲,这一优势与日常生活,身体表现,认知功能,自我评价的健康和生活满意度的不同水平无关。但是,在健康状况较好的人群中,优势往往更为明显。结论寿命和健康状况在最老的老年人中增加。从1915年出生的95岁婴儿的生存状况来看,与1905年相比,在整个健康和功能方面都有所改善,在健康状况良好的人群中,有更大的改善趋势。
更新日期:2020-01-13
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