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Treatment of latent tuberculosis infection based on the interferon-gamma releasing assay in allogeneic stem cell transplant recipients.
Clinical Infectious Diseases ( IF 8.2 ) Pub Date : 2020-01-13 , DOI: 10.1093/cid/ciaa030
Joung Ha Park 1 , Eun-Ji Choi 2 , Han-Seung Park 2 , Sang-Ho Choi 1 , Sang-Oh Lee 1 , Yang Soo Kim 1 , Jun Hee Woo 1 , Jung-Hee Lee 2 , Je-Hwan Lee 2 , Kyoo-Hyung Lee 2 , Tae Sun Shim 3 , Sung-Han Kim 1
Affiliation  

In hematopoietic stem cell transplant recipients, the incidence of tuberculosis in positive interferon-γ release assay (IGRA) without isoniazid prophylaxis (3.58/100 person-years) was higher than in negative or indeterminate IGRA (1.15/100 person-years; P = .01) and in positive IGRA with isoniazid prophylaxis (0/100 person-years; P = .09). The number needed to treat was 22 (95% confidence interval, 12–99) with positive IGRA results.

中文翻译:

基于同种异体干细胞移植受者γ-干扰素释放测定的潜伏性结核感染治疗。

在造血干细胞移植受者中,未进行异烟肼预防的阳性干扰素-γ释放试验(IGRA)中的结核发生率(3.58 / 100人年)高于阴性或不确定IGRA(1.15 / 100人年;P = .01)和IGRA阳性且预防异烟肼(0/100人年; P = .09)。IGRA结果阳性需要治疗的人数为22(95%置信区间12–99)。
更新日期:2020-01-13
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