In the current issue of Acta Physiologica, Larsson and colleagues examined the effect of chaperone co‐inducer BGP‐15 on impaired contractile function of the slow‐twitch soleus muscles in a rat intensive care unit (ICU) model.¹ They found that BGP‐15 improves myofibrillar function in the soleus muscle after 5 days exposure to the ICU condition, which is accompanied by improved mitochondrial morphology/biogenesis and reduced oxidative post‐translational modifications (PTMs) of myosin molecules.

中文翻译：

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BGP-15：重症肌病的潜在治疗剂。

在当前一期《生理生理学》中，Larsson及其同事在大鼠重症监护病房（ICU）模型中检查了伴侣伴侣诱导剂BGP-15对慢肌比目鱼肌收缩功能受损的影响。¹他们发现，在ICU条件下暴露5天后，BGP-15改善了比目鱼肌的肌原纤维功能，并伴有线粒体形态/生物发生的改善和肌球蛋白分子的氧化翻译后修饰（PTM）的减少。