Hypertension during pregnancy and preeclampsia are associated with increased arterial thrombotic risk in later life. Whether these complications are associated with risk of venous thromboembolism (VTE) on the short term after pregnancy and on the long term, that is, outside pregnancy, is largely unknown. We conducted a nationwide cohort study in women with at least 1 pregnancy and their first VTE risk by linking the Dutch perinatal registry (Perined) to anticoagulation clinics. We used Cox proportional hazard models to estimate hazard ratios (HRs) and corresponding 95% CI for VTE risk in women with hypertension during pregnancy, women with preeclampsia, compared with women with uncomplicated pregnancies (reference). A total of 1 919 918 women were followed for a median of 13.7 (interquartile range, 7.6–19.2) years for a total of 24 531 118 person-years in which 5759 first VTEs occurred; incidence rate: 2.3 (95% CI, 2.3–2.4) per 10 000 person-years. In the first pregnancy and 3-month postpartum period, VTE risk was higher in women with hypertension, HR, 2.0 (95% CI, 1.7–2.4), and highest among women with preeclampsia, HR, 7.8 (95% CI, 5.4–11.3), versus the reference group. On the long term, women with hypertension during pregnancy and preeclampsia had a higher VTE risk: HR, 1.5 (95% CI, 1.4–1.6) and HR, 2.1 (95% CI, 1.8–2.4), respectively, versus the reference group. When excluding events during pregnancy and postpartum, these HRs were 1.4 (95% CI, 1.3–1.5) and 1.6 (95% CI, 1.4–2.0), respectively. In conclusion, hypertension during pregnancy and preeclampsia are associated with an increased VTE risk during pregnancy and postpartum period and in the 13 years after.

中文翻译：

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妊娠高血压并发症和静脉血栓栓塞风险

妊娠期高血压和先兆子痫与晚年动脉血栓形成风险增加有关。这些并发症是否与妊娠后短期和长期（即妊娠外）发生静脉血栓栓塞 (VTE) 的风险有关，目前尚不清楚。我们通过将荷兰围产期登记处 (Perined) 与抗凝诊所联系起来，对至少有 1 次怀孕和首次 VTE 风险的女性进行了一项全国性队列研究。我们使用 Cox 比例风险模型来估计妊娠期高血压女性、先兆子痫女性与无并发症妊娠女性的 VTE 风险的风险比 (HR) 和相应的 95% CI（参考）。总共对 1 919 918 名女性进行了随访，中位数为 13.7（四分位距，7.6-19。2) 总共 24 531 118 人年，其中发生了 5759 次首次 VTE；发病率：每 10 000 人年 2.3（95% CI，2.3–2.4）。在第一次怀孕和产后 3 个月期间，高血压女性的 VTE 风险较高，HR，2.0（95% CI，1.7-2.4），而先兆子痫女性的 VTE 风险最高，HR，7.8（95% CI，5.4-） 11.3），与参考组。从长期来看，妊娠期高血压和先兆子痫妇女的 VTE 风险更高：与参考组相比，HR 分别为 1.5（95% CI，1.4-1.6）和 HR，2.1（95% CI，1.8-2.4） . 当排除妊娠和产后事件时，这些 HR 分别为 1.4（95% CI，1.3-1.5）和 1.6（95% CI，1.4-2.0）。综上所述，