Supplemental Digital Content is available in the text. This study sought to analyze blood pressure trends in children with Down syndrome at multiple centers. A multicenter, retrospective, cross-sectional study was performed. All patients were <18 years and had a diagnosis of Down syndrome. Existing comorbidities were nonexclusionary. For each patient, 3 blood pressure recordings were obtained from routine clinic visits. In total, 887 patients with 2661 total blood pressure recordings were included in this study. The average blood pressure percentile for patients was 38.87 with a median percentile of 31.5. Age, sex, and race were not predictive of blood pressure percentile. Compared with established data from the National Heart Lung and Blood Institute and National Health and Nutrition Examination Survey cohort (ages 8–18 years), blood pressure in our Down syndrome population was statistically lower by 6.1 percentile points (P<0.001), with the greatest difference at higher blood pressure percentiles (P<0.001). Only 10% of all Down syndrome cohort blood pressure recordings were greater than the National Heart Lung and Blood Institute/National Health and Nutrition Examination Survey 70th percentile, with no patients meeting criteria for prehypertension or hypertension. Additional comparisons against American Academy of Pediatrics data were similar and statistically significant. In children with Down syndrome, there is a 12 percentile point reduction in baseline blood pressure compared with age- and height-matched controls reported in the National Heart Lung and Blood Institute/National Health and Nutrition Examination Survey and American Academy of Pediatrics cohorts. This data can potentially be utilized in the evaluation and care of persons with Down syndrome in their pediatric medical homes.

中文翻译：

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唐氏综合症儿童血压下降

补充数字内容在文本中可用。本研究旨在分析多个中心唐氏综合症儿童的血压趋势。进行了一项多中心、回顾性、横断面研究。所有患者均<18岁，诊断为唐氏综合症。现有的合并症是非排他性的。对于每位患者，从常规门诊就诊中获得 3 次血压记录。本研究共纳入 887 名患者，共记录了 2661 次血压。患者的平均血压百分位数为 38.87，中位数百分位数为 31.5。年龄、性别和种族不能预测血压百分位数。与国家心肺和血液研究所和国家健康和营养检查队列（8-18 岁）的既定数据相比，我们的唐氏综合症人群的血压在统计学上降低了 6.1 个百分点（P<0.001），在较高的血压百分位处差异最大（P<0.001）。只有 10% 的唐氏综合征队列血压记录高于国家心肺和血液研究所/国家健康和营养检查调查的第 70 个百分位，没有患者符合高血压前期或高血压的标准。与美国儿科学会数据的其他比较相似且具有统计学意义。与美国国家心肺和血液研究所/国家健康与营养检查调查和美国儿科学会队列中报告的年龄和身高匹配的对照相比，唐氏综合症儿童的基线血压降低了 12 个百分点。