Developing multifunctional carrier-free nanomedicine with high efficacy attracts tremendous attention in cancer treatment. Here, we develop selenium-containing carrier-free assemblies with aggregation-induced emission (AIE) property, which achieve the combination of cancer radiotherapy with chemotherapy. Under γ-radiation, diselenide bonds in the assemblies can be cleaved to form seleninic acid, which exhibits anticancer activity by upregulating the reactive oxygen species (ROS) levels in cancer cells. The incorporation of AIE groups further endows the selenium-containing assemblies with the ability of bioimaging. Their self-assembly behavior change under γ-radiation can be consequently observed in situ. The system combines cancer radiotherapy with chemotherapy, which exhibits improved anticancer activity.

中文翻译：

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具有聚集诱导发射特性的含硒无载体组件将癌症放射疗法与化学疗法相结合

开发高效的多功能无载体纳米药物在癌症治疗中引起了极大的关注。在这里，我们开发了具有聚集诱导发射（AIE）特性的含硒无载体组件，实现了癌症放疗与化疗的结合。在 γ 辐射下，组件中的二硒键可以裂解形成硒酸，通过上调癌细胞中的活性氧 (ROS) 水平而表现出抗癌活性。AIE 基团的加入进一步赋予了含硒组件生物成像的能力。因此可以原位观察到它们在 γ 辐射下的自组装行为变化。该系统将癌症放射疗法与化学疗法相结合，从而提高了抗癌活性。