Acinetobacter baumannii is well known for causing hospital-associated infections due in part to its intrinsic antibiotic resistance as well as its ability to remain viable on surfaces and resist cleaning agents. In a previous publication, A. baumannii strain AB5075 was studied by transposon mutagenesis and 438 essential gene candidates for growth on rich-medium were identified. The Seattle Structural Genomics Center for Infectious Disease entered 342 of these candidate essential genes into our pipeline for structure determination, in which 306 were successfully cloned into expression vectors, 192 were detectably expressed, 165 screened as soluble, 121 were purified, 52 crystalized, 30 provided diffraction data, and 29 structures were deposited in the Protein Data Bank. Here, we report these structures, compare them with human orthologs where applicable, and discuss their potential as drug targets for antibiotic development against A. baumannii.

中文翻译：

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走向鲍曼不动杆菌药物靶的结构组。

鲍曼不动杆菌引起医院相关的感染是众所周知的，部分原因是其固有的抗生素抗性以及其在表面上保持活力和抵抗清洁剂的能力。在以前的出版物中，通过转座子诱变研究了鲍曼不动杆菌AB5075菌株，并鉴定了438种在丰富培养基上生长的必需基因候选物。西雅图传染病结构基因组学中心将342个这些候选必需基因输入我们的结构测定管道，其中成功克隆了306个表达载体，可检测到192个表达，可溶性筛选165个，纯化了121个，结晶52个，其中30个提供的衍射数据，蛋白质数据库中保存了29个结构。在这里，我们报告这些结构，