Precontrolled Alignment of Graphite Nanoplatelets in Polymeric Composites Prevents Bacterial Attachment.,Small

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Precontrolled Alignment of Graphite Nanoplatelets in Polymeric Composites Prevents Bacterial Attachment.
Small ( IF 13.0 ) Pub Date : 2020-01-09 , DOI: 10.1002/smll.201904756
Santosh Pandit ₁ , Karolina Gaska ₂ , Venkata R S S Mokkapati ₁ , Emanuele Celauro ₁ , Abderahmane Derouiche ₁ , Sven Forsberg ₃ , Magnus Svensson ₄ , Roland Kádár ₂ , Ivan Mijakovic ₁

Affiliation

Graphene coatings composed of vertical spikes are shown to mitigate bacterial attachment. Such coatings present hydrophobic edges of graphene, which penetrate the lipid bilayers causing physical disruption of bacterial cells. However, manufacturing of such surfaces on a scale required for antibacterial applications is currently not feasible. This study explores whether graphite can be used as a cheaper alternative to graphene coatings. To examine this, composites of graphite nanoplatelets (GNP) and low-density polyethylene (LDPE) are extruded in controlled conditions to obtain controlled orientation of GNP flakes within the polymer matrix. Flakes are exposed by etching the surface of GNP-LDPE nanocomposites and antibacterial activity is evaluated. GNP nanoflakes on the extruded samples interact with bacterial cell membranes, physically damaging the cells. Bactericidal activity is observed dependent on orientation and nanoflakes density. Composites with high density of GNP (≥15%) present two key advantages: i) they decrease bacterial viability by a factor of 99.9999%, which is 10 000-fold improvement on the current benchmark, and ii) prevent bacterial colonization, thus drastically reducing the numbers of dead cells on the surface. The latter is a key advantage for longer-term biomedical applications, since these surfaces will not have to be cleaned or replaced for longer periods.

中文翻译：

聚合物复合材料中的石墨纳米片的预控制排列可防止细菌附着。

显示了由垂直尖峰组成的石墨烯涂层可减轻细菌附着。这样的涂层呈现出石墨烯的疏水性边缘，其渗入脂质双层，导致细菌细胞的物理破坏。然而，目前在抗菌应用所需的规模上制造这种表面是不可行的。这项研究探讨了石墨是否可以用作石墨烯涂层的便宜替代品。为了对此进行检验，在受控条件下挤出石墨纳米片（GNP）和低密度聚乙烯（LDPE）的复合材料，以在聚合物基质中获得GNP薄片的受控取向。通过蚀刻GNP-LDPE纳米复合材料的表面来暴露薄片，并评估其抗菌活性。挤出样品上的GNP纳米片与细菌细胞膜相互作用，物理损坏细胞。观察到杀菌活性取决于取向和纳米薄片密度。具有高GNP（≥15％）密度的复合材料具有两个主要优势：i）将细菌生存力降低99.9999％，是当前基准的10000倍，并且ii）防止细菌定居，从而大大地减少表面上死细胞的数量。后者是长期生物医学应用的关键优势，因为这些表面无需长时间清洁或更换。ii）防止细菌定植，从而大大减少了表面上死细胞的数量。后者是长期生物医学应用的关键优势，因为这些表面无需长时间清洁或更换。ii）防止细菌定植，从而大大减少了表面上死细胞的数量。后者是长期生物医学应用的关键优势，因为这些表面无需长时间清洁或更换。

更新日期：2020-02-07

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