Influenza C virus (ICV) is a common yet under-recognized cause of acute respiratory illness. ICV seropositivity has been found to be as high as 90% by 7-10 years of age, suggesting that most people are exposed to ICV at least once during childhood. Due to difficulty detecting ICV by cell culture, epidemiologic studies of ICV likely have underestimated the burden of ICV infection and disease. Recent development of highly sensitive RT-PCR has facilitated epidemiologic studies that provide further insights into the prevalence, seasonality, and course of ICV infection. In this review, we summarize the epidemiology and clinical characteristics of ICV.

中文翻译：

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丙型流感病毒的流行病学和临床特征。

丙型流感病毒（ICV）是急性呼吸道疾病的常见但未得到充分认识的原因。据发现，到7-10岁时，ICV的血清阳性率为90％，这表明大多数人在儿童时期至少接触过一次ICV。由于难以通过细胞培养检测ICV，因此ICV的流行病学研究可能低估了ICV感染和疾病的负担。高灵敏度RT-PCR的最新发展促进了流行病学研究，这些研究为ICV感染的流行，季节性和病程提供了进一步的见识。在这篇综述中，我们总结了ICV的流行病学和临床特征。