An efficient and mild synthetic route to the convenient one-pot preparation of polyfunctionalized dihydro-2-oxypyrroles has been developed and catalyzed via glycine amino acid as a natural bio-based and biodegradable catalyst using imin-based four condensation domino reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde via tandem Michael–Mannich cyclocondensation reaction under ambient temperature. The reactions complete in less time, but the products are obtained in outstanding yields. This environmentally friendly method includes the noticeable properties such as bio-based and green catalyst, direct workup without column chromatographic separation, cost-effective, mild and simple synthesis, one-pot procedure and high atom economy.

已经开发了一种高效，温和的合成途径，以方便的一锅制备多官能化二氢-2-氧基吡咯，并通过甘氨酸氨基酸作为天然生物基和可生物降解的催化剂，使用基于亚胺的胺，二烷基四胺基缩合多米诺反应进行催化。在环境温度下，通过迈克尔-曼尼希串联缩合反应生成乙炔二羧酸盐和甲醛。反应在较短的时间内完成，但是以优异的产率获得了产物。这种对环境友好的方法包括引人注目的特性，例如生物基和绿色催化剂，无需柱色谱分离即可直接进行后处理，具有成本效益，温和简单的合成，一锅法和高原子经济性。