Manganese-Catalyzed Enantioselective Hydrogenation of Simple Ketones Using an Imidazole-Based Chiral PNN Tridentate Ligand,Synlett

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Manganese-Catalyzed Enantioselective Hydrogenation of Simple Ketones Using an Imidazole-Based Chiral PNN Tridentate Ligand
Synlett ( IF 1.7 ) Pub Date : 2020-01-10 , DOI: 10.1055/s-0039-1690783
Fei Ling ₁ , Jiachen Chen ₁ , Sanfei Nian ₁ , Huacui Hou ₁ , Xiao Yi ₁ , Feifei Wu ₁ , Min Xu ₂ , Weihui Zhong _{1,

2}

Affiliation

A series of Mn(I) catalysts containing imidazole-based chiral PNN tridentate ligands with controllable ‘side arm’ groups have been established, enabling the inexpensive base-promoted asymmetric hydrogenation of simple ketones with outstanding activities (up to 8200 TON) and good enantioselectivities (up to 88.5% ee). This protocol features wide substrate scope and functional group tolerance, thereby providing easy access to a key intermediate of crizotinib.

中文翻译：

使用基于咪唑的手性 PNN 三齿配体对简单酮进行锰催化的对映选择性氢化

已经建立了一系列含有咪唑基手性 PNN 三齿配体和可控“侧臂”基团的 Mn(I) 催化剂，使具有出色活性（高达 8200 TON）和良好对映选择性的简单酮的廉价碱促进不对称氢化成为可能（高达 88.5% ee）。该协议具有广泛的底物范围和官能团耐受性，从而可以轻松获得克唑替尼的关键中间体。

更新日期：2020-01-10

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