Justicia spicigera is a plant used in traditional Mexican medicine to treat various diseases such as heart diseases and to improve blood circulation, with little scientific evidence. Therefore, this study evaluated the effect of the leaves of the plant and of kaempferitrin (main active ingredient), on biochemical, physiological, and inflammation markers related to obesity induced by a high-fat diet in male Wistar rats for eight weeks. The results indicated that J. spicigera powder has the ability to significantly decrease (p ≤ 0.05) the percentage of accumulated fat, and consequently, weight gain, as well as serum triglyceride concentrations. In addition, both J. spicigera powder and kaempferitrin generated transcriptional adaptations by negatively modulating the expression of pro-inflammatory genes such as Tlr4, Tnf-α, Nlrp3, Caspase-1, Il-18, Il-1β, Srebp-1c, Ppar-γ and Ucp2 and overexpressing Ppar-α.

Justicia spicigera是一种在墨西哥传统医学中用于治疗各种疾病（例如心脏病）和改善血液循环的植物，但缺乏科学证据。因此，本研究评估了雄性Wistar大鼠连续八周对高脂饮食诱导的肥胖相关的生化，生理和炎症指标的影响，研究了植物叶片和山楂铁蛋白（主要活性成分）的作用。结果表明，S。spicigera散粉具有显着降低（p≤0.05）累积脂肪的百分比的能力，因此可以显着降低体重增加以及血清甘油三酸酯的浓度。此外，两个J. spicigera粉末和kaempferitrin通过促炎基因，例如表达负调节产生的转录改编TLR4，TNF-α，NLRP3，胱天蛋白酶1，IL-18，IL-1β，SREBP-1c中， PPAR-γ和UCP2和过表达PPAR -α。