Abstract The superparamagnetic Fe3O4 magnetic nanoparticles have attracted a considerable amount of attention in biomedical fields such as drug delivery, MRI contrast, and hyperthermia treatment. To enable these varied applications of Fe3O4 nanoparticles, it is essential to synthesise them in various sizes, from several nanometres to several hundred nanometres. The synthesis of superparamagnetic Fe3O4 nanoparticles was carried out using the polyol method, which is based on the polar polyol and synthesis was attained via a stepwise phase transformation. The concentration of sodium acetate (NaOAc) used to control the rate of hydrolysis of iron precursor and the molar ratio of the iron precursor and water were controlled to vary the size of Fe3O4 particles. It was found that the particle size decreased as the concentration of NaOAc increased and decreased even more when the molar ratio of the iron precursor was decreased. Particles ranging from 11 nm to 338 nm in size were produced using this method. The correlation between starting materials, particle size, and morphology was thus investigated from these results.

中文翻译：

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多元醇法合成不同尺寸的Fe3O4纳米颗粒

摘要 超顺磁性Fe3O4磁性纳米粒子在药物输送、MRI造影、热疗等生物医学领域引起了广泛关注。为了实现 Fe3O4 纳米粒子的这些不同应用，必须将它们合成为各种尺寸，从几纳米到几百纳米。超顺磁性 Fe3O4 纳米粒子的合成是使用多元醇法进行的，该法基于极性多元醇，通过逐步相变实现合成。用于控制铁前体水解速率的乙酸钠 (NaOAc) 浓度以及铁前体与水的摩尔比被控制以改变 Fe3O4 颗粒的大小。发现粒径随着 NaOAc 浓度的增加而减小，当铁前体的摩尔比减小时，粒径减小得更多。使用这种方法生产了尺寸范围为 11 nm 至 338 nm 的颗粒。因此从这些结果研究了起始材料、粒度和形态之间的相关性。