Microwave (MW) thermal therapy has been vigorously developed in recent years because of its better therapeutic efficiency and smaller side effects compared with traditional tumor treatment methods. In order to promote the tumor cell apoptosis under MW irradiation and achieve better therapeutic effect and prognosis, various microwave sensitizers have been developed. Metal organic frameworks (MOFs) have become one of the most popular materials for microwave sensitization due to their diverse morphology, porous surface and good biodegradability. However, the harsh preparation conditions and long growth time are insurmountable shortcomings of MOFs. Besides, the spongy porous structure of MOFs is not conducive to the retention of ions, leading to insufficient friction and collision between ions under MW radiation. Herein, we synthesized a kind of open-mouthed Zr MOF-derived nano-popcorns (ZDNPs) with the size of about 250 nm by a rapid sonochemical aerosol flow strategy. Compared with UIO-66, the open-mouthed ZDNPs have a better ability to entrap more ions due to their big cracks on the surface, thus improving their MW sensitization performance. The MW heating experiments in vitro present that the net temperature change value of ZDNP was 120% higher than UIO-66 at the same concentration, proving that ZDNP had a higher MW-thermo conversion efficiency than UIO-66, which provided an unprecedented direction for the exploration of more diversified MW sensitizers.

中文翻译：

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通过声化学合成的MOF衍生的纳米爆米花，可作为有效的肿瘤微波热敏剂。

与传统的肿瘤治疗方法相比，微波（MW）热疗法由于其更好的治疗效率和更小的副作用，近年来得到了大力发展。为了促进微波照射下肿瘤细胞的凋亡并达到更好的治疗效果和预后，人们开发了各种微波敏化剂。金属有机骨架（MOF）由于其形态多样，多孔的表面和良好的生物降解性，已成为微波敏化的最流行材料之一。但是，苛刻的准备条件和较长的成长时间是财政部难以克服的缺点。此外，MOFs的海绵状多孔结构不利于离子的保留，导致在MW辐射下离子之间的摩擦和碰撞不足。在这里 我们通过快速的声化学气溶胶流动策略合成了一种开口的Zr MOF衍生的纳米爆米花（ZDNP），其尺寸约为250 nm。与UIO-66相比，敞开式ZDNP由于其表面上的大裂纹而具有更好的捕获更多离子的能力，从而提高了其MW敏化性能。体外MW加热实验表明，在相同浓度下，ZDNP的净温度变化值比UIO-66高120％，证明ZDNP比UIO-66具有更高的MW-热转化效率，这为UIO-66提供了前所未有的发展方向。探索更多样化的兆瓦敏化剂。开口的ZDNP由于其表面上的大裂纹而具有更好的捕获更多离子的能力，从而提高了其MW敏化性能。体外MW加热实验表明，在相同浓度下，ZDNP的净温度变化值比UIO-66高120％，证明ZDNP比UIO-66具有更高的MW-热转化效率，这为UIO-66提供了前所未有的发展方向。探索更多样化的兆瓦敏化剂。开口的ZDNP由于其表面上的大裂纹而具有更好的捕获更多离子的能力，从而提高了其MW敏化性能。体外MW加热实验表明，在相同浓度下，ZDNP的净温度变化值比UIO-66高120％，证明ZDNP比UIO-66具有更高的MW-热转化效率，这为UIO-66提供了前所未有的发展方向。探索更多样化的兆瓦敏化剂。