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Cyclometallic iridium-based nanorods for chemotherapy/photodynamic therapy
Materials Letters ( IF 3 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.matlet.2020.127346
Wan Liu , Nan Song , Yuanyuan Li , Yang Liu , Li Chen , Shi Liu , Zhigang Xie

Abstract The combination of photodynamic therapy (PDT) and chemotherapy can be used to enhance antitumor therapeutic efficacy, especially without increasing the dosage of chemotherapy drugs. Therefore, we design a novel cyclometallic Ir(III) nanocomposites (Ir-PTX) attached with chemotherapy drugs paclitaxel (PTX) by ester bonds for combination of PDT and chemotherapy. The Ir-PTX can self-assemble into nanorods and be taken up by cells. The nanorods can generate singlet oxygen (1O2) to kill cancer cells. Furthermore, the release of PTX after the cleavage of the ester bonds induces apoptosis of tumor cells. Based on the above, the cyclometallic iridium-based nanorods have broad prospects for chemo-photodynamic therapy.

中文翻译:

用于化学疗法/光动力疗法的环金属铱基纳米棒

摘要 光动力疗法(PDT)与化学疗法的结合可增强抗肿瘤疗效,尤其是在不增加化学疗法药物剂量的情况下。因此,我们设计了一种新型的环状金属 Ir(III) 纳米复合材料 (Ir-PTX),通过酯键与化疗药物紫杉醇 (PTX) 相连,用于 PDT 和化疗的结合。Ir-PTX 可以自组装成纳米棒并被细胞吸收。纳米棒可以产生单线态氧 (1O2) 来杀死癌细胞。此外,酯键断裂后 PTX 的释放诱导肿瘤细胞凋亡。综上所述,环金属铱基纳米棒在化学光动力治疗方面具有广阔的前景。
更新日期:2020-05-01
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