Blood-borne chronic viral infections in a large cohort of immigrants in southern Italy: A seven-centre, prospective, screening study.,Travel Medicine and Infectious Disease

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Blood-borne chronic viral infections in a large cohort of immigrants in southern Italy: A seven-centre, prospective, screening study.
Travel Medicine and Infectious Disease ( IF 6.3 ) Pub Date : 2020-01-13 , DOI: 10.1016/j.tmaid.2020.101551
Nicola Coppola ₁ , Caterina Monari ₁ , Loredana Alessio ₂ , Lorenzo Onorato ₃ , Luciano Gualdieri ₄ , Caterina Sagnelli ₅ , Carmine Minichini ₆ , Evangelista Sagnelli ₆ , Giovanni Di Caprio ₂ , Lorenzo Surace ₇ , Gaetano Scotto ₈ , Margherita Macera ₉ , Gianfranco Griffo ₇ , Italo Francesco Angelillo ₁₀ , Mariantonietta Pisaturo ₃

Affiliation

Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Italy; Infectious Diseases Unit, AORN Sant'Anna e San Sebastiano, Caserta, Italy.
Infectious Diseases Unit, AORN Sant'Anna e San Sebastiano, Caserta, Italy; Medical Center, Centro Sociale ex Canapificio, Caserta, Italy.
Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Italy; Medical Center, Centro di Accoglienza "La tenda di Abramo", Caserta, Italy.
Medical Center, Centro per la Tutela della Salute degli Immigrati, Naples, Italy.
Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Italy; Medical Center, Centro Suore Missionarie della Carità, Naples, Italy.
Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Italy.
Centro Medicina del Viaggiatore e delle Migrazioni ASP Catanzaro, Presidio Ospedaliero "Giovanni Paolo II", Lamezia Terme, Italy.
Infectious Diseases Unit, Foggia, Italy.
Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Italy; Medical Center, Centro Sociale ex Canapificio, Caserta, Italy.
Department of Experimental Medicine, University of Campania, Naples, Italy.

Background

Aim of this study was to evaluate the prevalence of blood-borne chronic viral infections in immigrants living in southern Italy and identify factors associated to viral infections.

Methods

A prospective screening program was performed in seven clinical centers operating in Campania, Apulia and Calabria regions in southern Italy, in order to identify immigrants with HBV, HCV or HIV infections.

Results

Of 4,125 immigrants observed in the study period, 3,839 (93.0%) agreed to be screened: 381 (9.9%) resulted HBsAg-positive, 136 (3.5%) anti-HCV, 62 (1.6%) anti-HIV and 1,448 (37.7%) HBsAg-negative and anti-HBc-positive. Ongoing or previous HBV infection was observed more frequently in males (p = 0.02 and p < 0.001, respectively), whereas HIV infection in females (p = 0.01). Immigrants from western Africa showed a higher rate of HBsAg positivity (p < 0.0001), HBsAg negativity/anti-HBc positivity (p < 0.0001) and anti-HIV positivity (p = 0.004) compared with those from other geographical areas. At multivariate analysis, ongoing HBV infection was associated with male sex (OR 1.49, 95% CI: 1.04–2.14) and origin from western Africa (OR 4.67, 95% CI: 1.70–12.80) and eastern Europe (OR 3.44, 95% CI: 1.17–10.08). HCV infection showed the tendency to be more frequent among males (OR 1.84, 95% CI: 0.99–3.42). HIV infection was associated with an older age (OR 1.04, 95% CI: 1.01–1.06), origin from western Africa (OR 4.09, 95% CI: 1.26–13.29) and female sex (OR 2.38, 95% CI: 1.29–4,39; p = 0.006).

Conclusions

The high prevalence of HBV, HCV and HIV infections in our large cohort of immigrants should definitively prompt Italian Healthcare Authorities to develop adequate cost-effective screening policies.

中文翻译：

意大利南部一大批移民的血源性慢性病毒感染：一项七中心，前瞻性筛查研究。

背景

这项研究的目的是评估居住在意大利南部的移民中血源性慢性病毒感染的患病率，并确定与病毒感染相关的因素。

方法

在意大利南部的坎帕尼亚，普利亚和卡拉布里亚地区运营的七个临床中心进行了一项前瞻性筛查计划，以鉴定患有HBV，HCV或HIV感染的移民。

结果

在研究期间观察到的4,125名移民中，同意接受筛查的3,839名（93.0％）：HBsAg阳性的有381名（9.9％），抗HCV的有136名（3.5％），抗HIV的62名（1.6％）和1,448名（37.7）％）HBsAg阴性和抗HBc阳性。在男性中，进行中或以前的HBV感染更为频繁（分别为p = 0.02和p <0.001），而在女性中则为HIV感染（p = 0.01）。与其他地区的移民相比，来自西非的移民表现出更高的HBsAg阳性率（p <0.0001），HBsAg阴性/抗HBc阳性率（p <0.0001）和抗HIV阳性率（p = 0.004）。在多变量分析中，正在进行的HBV感染与男性（OR 1.49，95％CI：1.04–2.14）有关，且起源于西非（OR 4.67，95％CI：1.70-12.80）和东欧（OR 3.44，95％）。 CI：1.17-10.08）。HCV感染在男性中呈上升趋势（OR 1.84，95％CI：0.99–3.42）。HIV感染与年龄较大（OR 1.04，95％CI：1.01–1.06），起源于西非（OR 4.09，95％CI：1.26-13.29）和女性（OR 2.38，95％CI：1.29–1.2）相关。 4,39； p = 0.006）。