The roles of strawberry and honey phytochemicals on human health: A possible clue on the molecular mechanisms involved in the prevention of oxidative stress and inflammation,Phytomedicine

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The roles of strawberry and honey phytochemicals on human health: A possible clue on the molecular mechanisms involved in the prevention of oxidative stress and inflammation
Phytomedicine ( IF 6.7 ) Pub Date : 2020-01-11 , DOI: 10.1016/j.phymed.2020.153170
Maurizio Battino ₁ , Francesca Giampieri ₂ , Danila Cianciosi ₃ , Johura Ansary ₃ , Xiumin Chen ₄ , Di Zhang ₅ , Emilio Gil ₆ , Tamara Forbes-Hernández ₆

Affiliation

Background

Oxidative stress and inflammation contribute to the etiopathogenesis of several human chronic diseases, such as cancer, diabetes, cardiovascular diseases and metabolic syndrome. Besides classic stimuli, such as reactive oxidant species, endotoxins (i.e., bacteria lipopolysaccharide), cytokines or carcinogens, oxidative stress and inflammation can be triggered by a poor diet and an excess of body fat and energy intake. Strawberry and honey are common rich sources of nutrients and bioactive compounds, widely studied for their roles exerted in health maintenance and disease prevention.

Purpose

This review aims to summarize and update the effects of strawberry and honey against oxidative stress and inflammation, with emphasis on metabolism and on the main molecular mechanisms involved in these effects.

Methods

A wide range of literature, published in the last 10 years, elucidating the effects of strawberry and honey in preventing oxidative stress and inflammation both in vitro (whole matrix and digested fractions) and in vivo was collected from online electronic databases (PubMed, Scopus and Web of Science) and reviewed.

Results

Strawberry and honey polyphenols may potentially prevent the chronic diseases related to oxidative stress and inflammation. Several in vitro and in vivo studies reported the effects of these foods in suppressing the oxidative stress, by decreasing ROS production and oxidative biomarkers, restoring the antioxidant enzyme activities, ameliorating the mitochondrial antioxidant status and functionality, among others, and the inflammatory process, by modulating the mediators of acute and chronic inflammation essential for the onset of several human diseases. These beneficial properties are mediated in part through their ability to target multiple signaling pathways, such as p38 MAPK, AMPK, PI3K/Akt, NF-κB and Nrf2.

Conclusions

Available scientific literature show that strawberry and honey may be effective in preventing oxidative stress and inflammation. The deep evaluation of the factors that affect their metabolism as well as the assessment of the main molecular mechanisms involved are of extreme importance for the possible therapeutic and preventive benefit against the most common human diseases. However, published literature is still scarce so that deeper studies should be performed in order to evaluate the bioavailability of these food matrices and their effects after digestion.

中文翻译：

草莓和蜂蜜植物化学物质对人体健康的作用：可能的分子机制可能有助于预防氧化应激和炎症

背景

氧化应激和炎症促进了几种人类慢性疾病的发病机理，例如癌症，糖尿病，心血管疾病和代谢综合征。除了经典的刺激，例如反应性氧化剂，内毒素（即细菌脂多糖），细胞因子或致癌物外，不良饮食，身体脂肪和能量摄入过多也会引发氧化应激和炎症。草莓和蜂蜜是营养和生物活性化合物的常见丰富来源，由于它们在健康维护和疾病预防中的作用而被广泛研究。

目的

这篇综述旨在总结和更新草莓和蜂蜜对氧化应激和炎症的影响，重点是新陈代谢以及涉及这些影响的主要分子机制。

方法

最近十年发表的大量文献阐明了草莓和蜂蜜在体外（整个基质和消化部分）和体内预防氧化应激和炎症的作用，这些文献均来自在线电子数据库（PubMed，Scopus和Web of Science）并进行了审查。

结果

草莓和蜂蜜中的多酚可能会预防与氧化应激和炎症相关的慢性疾病。几项体外和体内研究报告了这些食物通过减少ROS的产生和氧化生物标记，恢复抗氧化酶活性，改善线粒体抗氧化状态和功能等，以及通过炎症过程来抑制氧化应激的作用。调节几种人类疾病发作必不可少的急性和慢性炎症的介质。这些有益的特性部分地通过它们靶向多种信号通路的能力来介导，例如p38 MAPK，AMPK，PI3K / Akt，NF-κB和Nrf2。