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Preparation and characterization of copper and zinc adsorbed cetylpyridinium and N-lauroylsarcosinate intercalated montmorillonites and their antibacterial activity.
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2020-01-11 , DOI: 10.1016/j.colsurfb.2020.110791 Günseli Özdemir 1 , Saadet Yapar 1
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2020-01-11 , DOI: 10.1016/j.colsurfb.2020.110791 Günseli Özdemir 1 , Saadet Yapar 1
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The main objective of the present study was the preparation and characterization of new cationic/anionic surfactants and Cu2+/Zn2+ modified montmorillonites and the evaluation of their potential applicability as antibacterial agents for topical applications. To evaluate the antibacterial activity of Cu2+ and Zn2+ by synergistic effect, as well as to reduce the well-known toxicity of these metal cations; cetylpyridinium (CP) and N-lauroylsarcosinate (SR) intercalated montmorillonite (Mt-CP-SR) was used as the host material. In addition to their role to capture the metal cations and inhibit their release in any contact medium, these surfactants also increase the efficacy of the material due to their antibacterial properties. The effect of surfactant loading on the adsorption behavior of the metal cations onto the Mt-CP was investigated using SR in two different concentrations, namely 0.7 and 1.0 CEC of sodium montmorillonite (Mt-Na). The samples prepared were characterized using SEM, ATR-FTIR, zeta potential, and XRD analyses and they were subjected to antibacterial tests using the "Standard Method Under Dynamic Contact Conditions" on the Gram positive S. aureus, and Gram negative E. coli. As confirmed with desorption and characterization studies, the addition of Cu2+/Zn2+ onto the Mt-CP-SR yielded double adsorbed amounts compared to that of the Mt-CP, which indicated that Cu2+/Zn2+ bound to SR- interacted with the Mt surface. In contrary of Zn2+ caused no considerable change in the antibacterial effect of the host, Cu2+ addition enhanced the antibacterial activity. The produced antibacterial agents have the potential use in dyes, polymer composites, personal care products, and topical medicinal applications.
中文翻译：
铜和锌吸附的十六烷基吡啶鎓和N-月桂酰肌氨酸盐插层蒙脱石的制备，表征及其抗菌活性。
本研究的主要目的是制备和表征新型阳离子/阴离子表面活性剂和Cu2 + / Zn2 +改性蒙脱土，并评估它们作为局部应用抗菌剂的潜在适用性。通过协同作用评估Cu2 +和Zn2 +的抗菌活性，以及降低这些金属阳离子的众所周知的毒性；十六烷基吡啶鎓（CP）和N-月桂酰肌氨酸盐（SR）插层蒙脱土（Mt-CP-SR）被用作主体材料。这些表面活性剂除了具有捕获金属阳离子并抑制其在任何接触介质中释放的作用外，还由于其抗菌性能而提高了材料的功效。使用两种不同浓度的SR（0.7和1.0 CEC的蒙脱石钠（Mt-Na））研究了表面活性剂负载量对金属阳离子在Mt-CP上的吸附行为的影响。使用SEM，ATR-FTIR，ζ电势和XRD分析对所制备的样品进行表征，并使用“动态接触条件下的标准方法”对革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌进行抗菌测试。如解吸和表征研究所证实的，与Mt-CP相比，在Mt-CP-SR上添加Cu2 + / Zn2 +产生了两倍的吸附量，这表明与SR-结合的Cu2 + / Zn2 +与Mt表面相互作用。与此相反，Zn2 +不会对宿主的抗菌作用产生重大影响，Cu 2+的添加增强了抗菌活性。产生的抗菌剂在染料，聚合物复合材料，个人护理产品和局部药物应用中具有潜在的用途。
更新日期：2020-01-13
中文翻译：
铜和锌吸附的十六烷基吡啶鎓和N-月桂酰肌氨酸盐插层蒙脱石的制备，表征及其抗菌活性。
本研究的主要目的是制备和表征新型阳离子/阴离子表面活性剂和Cu2 + / Zn2 +改性蒙脱土，并评估它们作为局部应用抗菌剂的潜在适用性。通过协同作用评估Cu2 +和Zn2 +的抗菌活性，以及降低这些金属阳离子的众所周知的毒性；十六烷基吡啶鎓（CP）和N-月桂酰肌氨酸盐（SR）插层蒙脱土（Mt-CP-SR）被用作主体材料。这些表面活性剂除了具有捕获金属阳离子并抑制其在任何接触介质中释放的作用外，还由于其抗菌性能而提高了材料的功效。使用两种不同浓度的SR（0.7和1.0 CEC的蒙脱石钠（Mt-Na））研究了表面活性剂负载量对金属阳离子在Mt-CP上的吸附行为的影响。使用SEM，ATR-FTIR，ζ电势和XRD分析对所制备的样品进行表征，并使用“动态接触条件下的标准方法”对革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌进行抗菌测试。如解吸和表征研究所证实的，与Mt-CP相比，在Mt-CP-SR上添加Cu2 + / Zn2 +产生了两倍的吸附量，这表明与SR-结合的Cu2 + / Zn2 +与Mt表面相互作用。与此相反，Zn2 +不会对宿主的抗菌作用产生重大影响，Cu 2+的添加增强了抗菌活性。产生的抗菌剂在染料，聚合物复合材料，个人护理产品和局部药物应用中具有潜在的用途。
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