Background

Loss of muscle mass with age may be a key player in metabolic dysregulation. We examined the associations between abdominal muscle area and density with lipids and lipoproteins.

Methods

One thousand eight hundred and sixty eight adults completed health history and physical activity questionnaires, provided venous blood samples for lipids and inflammatory biomarkers, and underwent computed tomography to quantify body composition. Associations between muscle area and density with multiple lipid measures were assessed with multivariable linear and logistic regression.

Results

The mean age and body mass index of participants was 65 years and 28 kg/m², respectively, and 50% were female. After adjustment for demographics, cardiovascular disease risk factors, lipid-lowering medications, physical activity, sedentary behavior, inflammatory biomarkers, and central obesity, a 1-standard deviation increase in total abdominal, stability, and locomotor muscle areas was associated with a 13%, 11%, and 8% lower high-density lipoprotein cholesterol level, respectively (P < .05). With similar adjustment, a 1-standard deviation increase in total abdominal and stability muscle area was associated with a 13% and 12% lower total cholesterol level, respectively (P < .01). Compared to the lowest quartiles of total, stability, and locomotor muscle area, those in the higher quartiles of muscle area had over a 40% reduction in the odds of triglyceride levels greater than 150 mg/dL (P < .05). Total abdominal muscle density was positively associated with total cholesterol (P < .05) but was not associated with the other lipid outcomes.

Conclusion

Maintaining adequate skeletal muscle mass with age may decrease specific lipid levels related to hyperlipidemia and development of cardiometabolic disease.

中文翻译：

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骨骼肌面积和密度与脂质和脂蛋白胆固醇水平相关：动脉粥样硬化的多种族研究。

背景

随着年龄的增长，肌肉量的减少可能是代谢失调的关键因素。我们检查了腹部肌肉面积 和 密度 与脂质和脂蛋白之间的关联。

方法

1868 名成年人完成了健康史和体力活动问卷调查，提供了血脂和炎症生物标志物的静脉血样本，并接受了计算机断层扫描以量化身体成分。使用多变量线性和逻辑回归评估肌肉面积和密度与多种脂质测量之间的关联。

结果

参与者的平均年龄和体重指数分别为 65 岁和 28 kg/m ²，其中 50% 为女性。在调整人口统计学、心血管疾病危险因素、降脂药物、体力活动、久坐行为、炎症生物标志物和中心性肥胖后，腹部总面积、稳定性和运动肌肉面积增加 1 个标准差与 13% 相关、11% 和 8% 的高密度脂蛋白胆固醇水平分别降低 ( P  < .05)。通过类似的调整，腹部总面积和稳定肌面积增加 1 个标准差分别与总胆固醇水平降低 13% 和 12% 相关（P < .01)。与总肌肉面积、稳定性和运动肌肉面积的最低四分位数相比，肌肉面积较高四分位数的人甘油三酯水平大于 150 mg/dL 的几率降低了 40% 以上（P  < .05）。总腹肌密度与总胆固醇呈正相关（P  < .05），但与其他血脂结果无关。

结论

随着年龄的增长保持足够的骨骼肌质量可能会降低与高脂血症和心脏代谢疾病发展相关的特定脂质水平。