One of the essential steps in every viral 'life' cycle is entry into the host cell. Membrane-enveloped viruses carry dedicated proteins to catalyse the fusion of the viral and cellular membrane. Herpesviruses feature a set of essential, structurally diverse glycoproteins on the viral surface that form a multicomponent fusion machinery, necessary for the entry mechanism. For Herpes simplex virus 1, these essential glycoproteins are gD, gH, gL and gB. In this review we describe the functions of the individual components, the potential interactions between them as well as the influence of post-translational modifications on the fusion mechanism.

中文翻译：

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疱疹病毒膜融合——团队努力。


每个病毒“生命”周期的重要步骤之一是进入宿主细胞。膜包膜病毒携带专用蛋白质来催化病毒和细胞膜的融合。疱疹病毒在病毒表面具有一组必需的、结构多样的糖蛋白，形成多组分融合机制，这是进入机制所必需的。对于单纯疱疹病毒 1 型，这些必需糖蛋白是 gD、gH、gL 和 gB。在这篇综述中，我们描述了各个组件的功能、它们之间的潜在相互作用以及翻译后修饰对融合机制的影响。