Human exposure to per- and polyfluorinated alkyl substances (PFASs) is a major public health concern because in the last decades several cases of overexposure of people to PFASs, in particular through contaminated water, occurred worldwide. In 2013-2017 a PFAS drinking water contamination was discovered and investigated in northern Italy (Veneto region) and high PFAS serum levels were detected in exposed people. 629 subjects were enrolled: 257 residing in municipalities in the areas under impact, 250 residing in municipalities in areas at presumed background exposure and 122 farmers living in contaminated rural areas producing and consuming own livestock and vegetables and frequently using well water. The highest PFAS serum concentrations (median PFOA concentrations 40 ng/g) were found in the subgroup of farmers. The main factors influencing PFAS serum levels of farmers were residence area and the related extent of drinking water contamination, gender, years of residence in the municipalities, well water consumption and consumption of own produced food. PFOA serum concentrations in farmers residing in the areas of the Veneto region impacted by PFAS contamination are among the highest found worldwide.

中文翻译：

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威尼托大区（意大利北部）受水污染影响的地区农民的血清全氟烷基物质浓度。

人体暴露于全氟和多氟烷基物质（PFAS）是一个主要的公共卫生问题，因为在过去的几十年中，全球发生了数起人们过度暴露于PFAS的案例，尤其是通过受污染的水。2013-2017年，在意大利北部（威尼托地区）发现并调查了全氟辛烷磺酸（PFAS）饮用水污染，并在暴露人群中检测到高全氟辛烷磺酸（PFAS）血清水平。招募了629名受试者：257名住在受影响地区的市政当局，250名住在假定背景暴露地区的市政当局，以及122名生活在受污染农村地区的农民，他们生产和消费自己的牲畜和蔬菜，并经常使用井水。在农民亚组中发现最高的PFAS血清浓度（中位数PFOA浓度为40 ng / g）。影响农民PFAS血清水平的主要因素是居住区和相关的饮用水污染程度，性别，在城市的居住年限，井水消耗量和自产食品的消耗量。威尼托地区受PFAS污染影响的农民中PFOA血清浓度是全球最高的。