Persistent and intrusive memories define a number of psychiatric disorders, including posttraumatic stress disorder and substance use disorder. In the latter, memory for drug-paired cues plays a critical role in sustaining compulsive drug use as these are potent triggers of relapse. As with many drugs, cocaine-cue associated memory is strengthened across presentations as cues become reliable predictors of drug availability. Recently, the targeting of cocaine-associated memory through disruption of the reconsolidation process has emerged as a potential therapeutic strategy; reconsolidation reflects the active process by which memory is re-stabilized after retrieval. In addition, a separate line of work reveals that neuroinflammatory markers, regulated by cocaine intake, play a role in memory processes. Our review brings these two literatures together by summarizing recent findings on cocaine-associated reconsolidation and cocaine-induced neuroinflammation. We discuss the interactions between reconsolidation processes and neuroinflammation following cocaine use, concluding with a new perspective on treatment to decrease risk of relapse to cocaine use.

中文翻译：

---

可卡因诱发的神经炎症可以解释与适应不良的可卡因有关的记忆吗？

持久性和侵入性记忆定义了许多精神疾病，包括创伤后应激障碍和物质使用障碍。在后者中，对药物配对线索的记忆在维持强迫性吸毒中起着至关重要的作用，因为它们是复发的有效诱因。与许多药物一样，可卡因提示相关的记忆在提示过程中会得到加强，因为提示已成为可靠的药物可用预测指标。最近，通过破坏重组过程来靶向可卡因相关的记忆已成为一种潜在的治疗策略。重新整合反映了检索后重新稳定内存的活跃过程。此外，另一项工作揭示了受可卡因摄入调节的神经炎症标记物在记忆过程中起作用。我们的综述通过总结可卡因相关的再巩固和可卡因诱导的神经炎症的最新发现，将这两个文献结合在一起。我们讨论了可卡因使用后再巩固过程与神经炎症之间的相互作用，并总结了减少可卡因使用复发风险的治疗新观点。