Three‐component electrosynthesis of spirooxindole‐pyran derivatives through a simple and efficient method,Journal of Heterocyclic Chemistry

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Three‐component electrosynthesis of spirooxindole‐pyran derivatives through a simple and efficient method
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-01-12 , DOI: 10.1002/jhet.3885
Somayeh Makarem ₁

Affiliation

An eco‐friendly and highly efficient process has been applied to synthesize spirooxindole‐pyran derivatives in a one‐pot container via a three‐component reaction of isatins, malononitrile, and an enolizable CH‐activated compound of diethyl 3‐oxopentanedioate under constant current in n‐propanol under a temperature of 50°C. The proposed method shows high yields through green reaction conditions along with other significant advantages. Among which stand out applying clean electrons as a reproducible source of energy instead of an organic catalyst, using an environmentally friendly solvent for instance propanol, a multicomponent reaction with mild condition happening in a one‐pot container, and no chromatographic separation.

中文翻译：

一种简单高效的方法合成螺氧杂吲哚-吡喃衍生物的三组分

生态友好的和高度有效的方法已通过靛红，丙二腈的三组分反应被应用于合成spirooxindole吡喃衍生物在一釜容器中，并且可烯醇化的Ç 下恒定二乙3-氧代戊二酸二的H-活化的化合物在温度为50°C的正丙醇中注入电流。所提出的方法在绿色反应条件下显示出高产率以及其他显着优点。其中脱颖而出的是使用清洁的电子代替有机催化剂作为可再生的能源，使用环境友好的溶剂（例如丙醇），在一个罐式容器中发生温和条件的多组分反应，并且不进行色谱分离。

更新日期：2020-01-13

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