Apathy is one of the most disabling neuropsychiatric symptoms in Parkinson's disease (PD) patients and has a higher prevalence in patients under subthalamic nucleus deep brain stimulation. Indeed, despite its effectiveness for alleviating PD motor symptoms, its neuropsychiatric repercussions have not yet been fully uncovered. Because it can be alleviated by dopaminergic therapies, especially D2 and D3 dopaminergic receptor agonists, the commonest explanation proposed for apathy after subthalamic nucleus deep brain stimulation is a too‐strong reduction in dopaminergic treatments. The objective of this study was to determine whether subthalamic nucleus deep brain stimulation can induce apathetic behaviors, which remains an important matter of concern. We aimed to unambiguously address this question of the motivational effects of chronic subthalamic nucleus deep brain stimulation.

中文翻译：

---

丘脑底核刺激损害动机：帕金森病冷漠的含义

冷漠是帕金森病 (PD) 患者中最致残的神经精神症状之一，在丘脑底核深部脑刺激下的患者中患病率更高。事实上，尽管它可以有效缓解 PD 运动症状，但其对神经精神的影响尚未完全揭开。因为它可以通过多巴胺能治疗来缓解，尤其是 D2 和 D3 多巴胺能受体激动剂，对丘脑底核深部脑刺激后的冷漠提出的最常见解释是多巴胺能治疗的过度减少。本研究的目的是确定丘脑下核深部脑刺激是否可以诱导冷漠行为，这仍然是一个值得关注的重要问题。