The glial cell line‐derived neurotrophic factor has a potent neuroprotective action on mesencephalic dopamine neurons, which are progressively lost in Parkinson's disease. Intrastriatal administration of this factor is a promising therapy for Parkinson's disease. Glial cell line‐derived neurotrophic factor is naturally produced in restricted cerebral regions, such as the striatum, septum, and thalamus; however, its effects in the adult brain remain under debate.

中文翻译：

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胶质细胞源性神经营养因子在成人中脑儿茶酚胺能神经元维持中的作用

神经胶质细胞系衍生的神经营养因子对中脑多巴胺神经元具有有效的神经保护作用，这些神经元在帕金森病中逐渐丧失。该因子的纹状体内给药是治疗帕金森病的有希望的疗法。神经胶质细胞系衍生的神经营养因子在受限的大脑区域自然产生，例如纹状体、隔膜和丘脑；然而，它对成人大脑的影响仍然存在争议。