BACKGROUND The reported incidence of Philadelphia-negative myeloproliferative neoplasms (MPNs) differs substantially between previous reports, likely due to true regional differences in incidence and/or variations in the quality and coverage of the cancer registers. OBJECTIVE We therefore assessed MPN incidence in Sweden during recent years using prospectively collected information captured in Swedish health registers. METHODS Patients with MPNs were identified through the Swedish Cancer Register and Swedish Blood Cancer Register between 2000 and 2014. Information on the Swedish population was obtained from the Human Mortality Database. Crude and age-standardized incidence rates of MPNs with 95% confidence intervals (CIs) were calculated. RESULTS A total of 6281 MPN cases were reported to the Swedish Cancer Register and Swedish Blood Cancer Register during 2000-2014. The age-standardized, to the Swedish population in 2000, incidence for all MPNs was 4.45 (95% confidence interval [CI] 4.34-4.56)/100 000 person-years. The age-standardized incidence for polycythemia vera was 1.48 (1.42-1.54), for essential thrombocythemia 1.60 (1.53-1.66) and for primary myelofibrosis 0.52 (0.48-0.56)/100 000 person-years, respectively. The incidence rate of MPNs was substantially higher in the older compared to the younger age groups. The incidence increased during the study period, likely to do better reporting and increasing age of the general population. CONCLUSION The reported MPN incidences in our study, which were in the higher interval of previously published studies, are likely more accurate compared to previous reports due to the population-based setting and high level of coverage in the Swedish Cancer and Blood Cancer Registers.

中文翻译：

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骨髓增生性肿瘤的发病率-瑞典一项基于人群的研究中按亚组和年龄划分的趋势。

背景费城阴性骨髓增生性肿瘤（MPN）的报道发病率在以前的报道中有很大差异，这可能是由于发病率的真正区域差异和/或癌症登记册的质量和覆盖范围存在差异所致。目的因此，我们使用瑞典健康登记册中收集的前瞻性信息评估了近年来瑞典的MPN发病率。方法在2000年至2014年之间通过瑞典癌症登记处和瑞典血液癌登记处确定MPN患者。有关瑞典人口的信息可从人类死亡率数据库中获得。计算出具有95％置信区间（CI）的MPN的粗略和年龄标准化发病率。结果2000-2014年间，瑞典癌症登记处和瑞典血液癌症登记处共报告了6281例MPN病例。按照瑞典2000年的年龄标准化，所有MPN的发生率为4.45（95％置信区间[CI] 4.34-4.56）/ 10万人年。真性红细胞增多症的年龄标准化发病率分别为1.48（1.42-1.54），原发性血小板增多症1.60（1.53-1.66）和原发性骨髓纤维化0.52（0.48-0.56）/ 100 000人年。与年龄较小的组相比，年龄较大的MPN的发生率要高得多。在研究期间，发病率增加，可能会更好地报告并增加普通人群的年龄。结论我们研究中报告的MPN发病率处于先前发表的研究的较高区间，