Relationship of volumetric bone mineral density by quantitative computed tomography with abdominal aortic calcification,Bone

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Relationship of volumetric bone mineral density by quantitative computed tomography with abdominal aortic calcification
Bone ( IF 3.5 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.bone.2020.115226
Sidong Li ₁ , Lu Yin ₁ , Kai Li ₂ , Bo Hu ₁ , Ling Wang ₂ , Yang Wang ₁ , Ning Li ₃ , Kai You ₄ , Yu Liu ₅ , Guoqin Liu ₆ , Shaoqi Xu ₇ , Lei Zhu ₈ , Jiman Shao ₉ , Xiaoguang Hao ₁₀ , Jun Zhou ₁₁ , Xiaoguang Cheng ₂ , Wei Li ₁

Affiliation

Medical Research & Biometrics Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Radiology, Beijing Jishuitan Hospital, Beijing, China.
Qingshan Lake Community Healthcare Service, Nanchang, China.
Shunyi Center for Disease Control and Prevention, Beijing, China.
Shenyang No. 242 Hospital, Shenyang, China.
People's Hospital of Jingle County, Shanxi, China.
Department of Radiology, Nanjing University of Chinese Medicine Affiliated Wujin Hospital of Traditional Chinese Medicine, Changzhou, China.
Department of Radiology, The People's Hospital of Dayi County, Chengdu, China.
Department of Radiology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Department of Radiology, Taiyuan Central Hospital, Taiyuan, China.
Department of Radiology, The 4(th) People's Hospital of Shenyang, Shenyang, China.

OBJECTIVE This multicenter study aimed to evaluate the association between volumetric bone mineral density (vBMD) and abdominal aortic calcification (AAC) in a Chinese population. METHODS Quantitative computed tomography (QCT) and Agatston score (AS) were used to measure vBMD and AAC, respectively, in 3457 participants during 2013-2017. The association between vBMD and AAC was assessed using multivariate regression analysis, adjusted for age, residence, education, body mass index, and other cardiovascular risk factors. RESULTS The mean age of women and men was 61.4 and 62.7 years, respectively. In total, 30.4% of women and 37.7% of men were found to have AAC. After full adjustment, higher vBMD was associated with lower AAC score (β, -0.095; 95% confidence interval [CI], -0.167 to -0.024; P = 0.0087) and lower AAC prevalence (odds ratio [OR], 0.873; 95% CI, 0.824 to 0.924; P < 0.0001) in men. Inverse trends were also observed in the association of vBMD quartile with AAC severity (lowest vs highest quartile; β = 0.235; 95% CI, 0.011 to 0.459; Ptrend < 0.0001) and AAC prevalence (lowest vs highest quartile; OR = 1.329; 95% CI, 1.087 to 1.625; Ptrend < 0.0001) in men. However, no significant result was obtained in women, except for the association between quartiles of vBMD and AAC score. CONCLUSIONS In our study, vBMD was inversely associated with AAC among men independent of age and shared risk factors. However, the association was not significant among women.

更新日期：2020-04-01

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