Abstract Dissolving microneedles (DMNs) have attracted extensive attention for transdermal drug delivery in recent years. Generally, the skin elasticity impedes DMNs to fully insert into skin thus optimized fabrication methods are needed to improve delivery efficiency. Here, we investigated the formulations of DMNs as the main influencing factors during the microneedle preparation process. Through the selection of the matrix materials and the optimization of the ratio and formulae, the DMNs can meet the requirements of convenient and effective drug delivery. For DMNs prepared with polyvinyl alcohol (PVA) as matrix material, the 25 wt% concentration of PVA was beneficial to prepare MNs, which MNs was able to focus drug on the part of MN tips. However, for DMNs fabricated with hyaluronic acid (HA), the increasing material concentration had a weaker ability to concentrate drug in MNs and increased the difficulty of preparing MNs. The computer simulation analysis was consistent with the results of the experiment, indicating the feasibility of modelling to investigate the preparation technology of DMNs that offer appropriate, convenient and highly efficient drug delivery.

中文翻译：

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药物-聚合物相互作用以控制溶解微针中药物分布的实验和理论研究

摘要 近年来，溶解微针（DMNs）在透皮给药方面引起了广泛关注。通常，皮肤弹性阻碍 DMNs 完全插入皮肤，因此需要优化制造方法来提高递送效率。在这里，我们研究了 DMN 的配方作为微针制备过程中的主要影响因素。通过基质材料的选择和配比和配方的优化，DMNs可以满足方便有效的给药要求。对于以聚乙烯醇 (PVA) 为基质材料制备的 DMNs, 25 wt% 的 PVA 浓度有利于制备 MNs, MNs 能够将药物集中在 MN 尖端部分。然而，对于用透明质酸 (HA) 制造的 DMN，物质浓度的增加使药物在MNs中的浓缩能力变弱，增加了制备MNs的难度。计算机模拟分析与实验结果一致，表明建模研究DMNs制备技术的可行性，提供适当、方便和高效的药物递送。