Seven previously undescribed compounds, including five coumarins, (+/-)-murpanitin A and murpanitins B-D, and a pair of spirocyclopentenone enantiomers, (+/-)-murrayaspiroketone, along with 14 known coumarin derivatives were isolated from the leaves and stems of Murraya paniculata (L.) Jack. Their structures were elucidated on the basis of comprehensive analysis of 1D and 2D NMR and HRMS spectroscopic data, and the absolute configurations were assigned via calculated and experimental ECD data. Three compounds showed moderate inhibitory effects on nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC50 values of 53.2 ± 8.9, 57.7 ± 5.8, and 53.2 ± 4.4 μM, respectively.

中文翻译：

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来自 Murraya paniculata (L.) Jack 叶和茎的香豆素和螺环戊烯酮衍生物

七种以前未描述的化合物，包括五种香豆素、(+/-)-murpanitin A 和 murpanitins BD，以及一对螺环戊烯酮对映异构体、(+/-)-murrayaspiroketone，以及 14 种已知的香豆素衍生物从叶和茎中分离出来。 Murraya paniculata (L.) Jack。在对一维和二维 NMR 和 HRMS 光谱数据进行综合分析的基础上阐明了它们的结构，并通过计算和实验 ECD 数据指定了绝对构型。三种化合物对 BV-2 小胶质细胞中脂多糖刺激的一氧化氮产生具有中等抑制作用，IC50 值分别为 53.2 ± 8.9、57.7 ± 5.8 和 53.2 ± 4.4 μM。