Abstract Magnetic biopolymer hybrid nanoparticles have gained a lot of attention in the field of biomedical applications. Here we present the synthesis of hyaluronic acid (HA)-coated magnetic clusters of superparamagnetic nanoparticles. Firstly, the superparamagnetic magnetite nanoparticles coated with oleic acid were synthesized and characterized in terms of size, composition and magnetic properties. Secondly, magnetic nanoclusters were prepared and wrapped with HA grafted with an ethylene glycol-based copolymer. The resulting nanostructures and nanobeads were characterized using electron microscopy, dynamic light scattering, thermogravimetric analysis and magnetic measurements. The clustering of magnetite nanoparticles facilitates magnetic purification, separation, rapid attraction and controlled positioning by high field gradient micro-magnet arrays. In addition, clusters could be formed in the presence of a fluorescent drug model, which demonstrates the possibility of dual functionalization of our hybrid nanosystems: magnetic responsiveness and drug encapsulation.

中文翻译：

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基于 Fe3O4 纳米团簇和用乙二醇基共聚物接枝的透明质酸的杂化纳米珠的合成和磁操作

摘要 磁性生物聚合物杂化纳米粒子在生物医学应用领域受到广泛关注。在这里，我们展示了透明质酸 (HA) 涂层的超顺磁性纳米粒子磁性簇的合成。首先，合成了涂有油酸的超顺磁性磁铁矿纳米颗粒，并在尺寸、组成和磁性方面进行了表征。其次，制备磁性纳米团簇并用乙二醇基共聚物接枝的HA包裹。使用电子显微镜、动态光散射、热重分析和磁测量表征所得纳米结构和纳米珠。磁铁矿纳米颗粒的聚集有利于磁性纯化、分离、通过高场梯度微磁阵列快速吸引和控制定位。此外，在荧光药物模型存在的情况下可以形成簇，这证明了我们的混合纳米系统双重功能化的可能性：磁响应和药物封装。