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Potential determinants during 'the first 1000 days of life' of sleep problems in school-aged children.
Sleep Medicine ( IF 3.8 ) Pub Date : 2020-01-11 , DOI: 10.1016/j.sleep.2019.12.020 Margreet W Harskamp-van Ginkel 1 , Ruth E Kool 1 , Lieke van Houtum 2 , Laura S Belmon 3 , Anke Huss 4 , Mai J M Chinapaw 5 , Tanja G M Vrijkotte 1
Sleep Medicine ( IF 3.8 ) Pub Date : 2020-01-11 , DOI: 10.1016/j.sleep.2019.12.020 Margreet W Harskamp-van Ginkel 1 , Ruth E Kool 1 , Lieke van Houtum 2 , Laura S Belmon 3 , Anke Huss 4 , Mai J M Chinapaw 5 , Tanja G M Vrijkotte 1
Affiliation
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STUDY OBJECTIVES
Early life determinants of sleep problems are mostly unknown. The first 1000 days of life (ie, the time between conception and a child's second birthday) is a period where the foundations for optimum health, growth and neurodevelopment are established. The aim of this explorative study is to identify potential early life determinants of sleep problems at age 7-8 years.
METHODS
Data from the Amsterdam Born Children and their Development cohort study (n = 2746) were analyzed. Sleep problems at age 7-8 years were reported by the caregiver in the 'Child Sleep Habits Questionnaire'. A higher total score indicates more sleep problems. After multiple imputation (n = 20), we studied multivariable associations between all potential determinants and sleep problems using regression analysis.
RESULTS
A higher pre-pregnancy body mass index (BMI) was associated with more sleep problems at age 7-8 years [β 0.12 (95% CI 0.05, 0.18)]. Children of mothers with symptoms of anxiety during pregnancy [β 0.06 (95% CI 0.03, 0.09)] and infancy period [β 0.04 (95% CI 0.00, 0.07)] had more sleep problems. Children of mothers drinking ≥1 glass of alcohol a day around 14 weeks of gestation had a 2 points higher sleep problem score [β 2.55 (95% CI 0.21, 4.89)] and children of mothers smoking ≥1 cigarette per day in that period had a one point higher score [β 1.07 (95% CI 0.10, 2.03)]. Infants with relative weight loss (delta BMI-SD) had a higher sleep problem score during childhood [β -0.32 (95%CI -0.60, -0.04)].
CONCLUSIONS
We identified several potential determinants during pregnancy and infancy associated with childhood sleeping problems. We encourage further research into these and other potential determinants to replicate results and to identify underlying mechanisms.
中文翻译：
学龄儿童睡眠问题“生命的头1000天”的潜在决定因素。
研究目标睡眠问题的早期生命决定因素多数是未知的。生命的前1000天（即从受孕到孩子第二个生日的时间）是建立最佳健康，生长和神经发育基础的时期。这项探索性研究的目的是确定7-8岁时睡眠问题的早期潜在决定因素。方法分析阿姆斯特丹出生儿童及其发展队列研究（n = 2746）的数据。照顾者在“儿童睡眠习惯调查表”中报告了7-8岁的睡眠问题。总分越高，表示睡眠问题越多。经过多次插补（n = 20），我们使用回归分析研究了所有潜在决定因素与睡眠问题之间的多变量关联。结果较高的孕前体重指数（BMI）与7-8岁时的更多睡眠问题相关[β0.12（95％CI 0.05，0.18）]。在妊娠期[β0.06（95％CI 0.03，0.09）]和婴儿期[β0.04（95％CI 0.00，0.07）]有焦虑症状的母亲的孩子有更多的睡眠问题。在妊娠14周左右每天喝≥1杯酒精的母亲的孩子的睡眠问题得分高出2分[β2.55（95％CI 0.21，4.89）]，而在此期间每天吸烟≥1支香烟的母亲的孩子的睡眠问题得分高。得分高1分[β1.07（95％CI 0.10，2.03）]。相对体重减轻（δBMI-SD）的婴儿在儿童时期有较高的睡眠问题评分[β-0.32（95％CI -0.60，-0.04）]。结论我们确定了妊娠和婴儿期与儿童睡眠问题相关的几个潜在决定因素。
更新日期：2020-01-13
中文翻译：
学龄儿童睡眠问题“生命的头1000天”的潜在决定因素。
研究目标睡眠问题的早期生命决定因素多数是未知的。生命的前1000天（即从受孕到孩子第二个生日的时间）是建立最佳健康，生长和神经发育基础的时期。这项探索性研究的目的是确定7-8岁时睡眠问题的早期潜在决定因素。方法分析阿姆斯特丹出生儿童及其发展队列研究（n = 2746）的数据。照顾者在“儿童睡眠习惯调查表”中报告了7-8岁的睡眠问题。总分越高，表示睡眠问题越多。经过多次插补（n = 20），我们使用回归分析研究了所有潜在决定因素与睡眠问题之间的多变量关联。结果较高的孕前体重指数（BMI）与7-8岁时的更多睡眠问题相关[β0.12（95％CI 0.05，0.18）]。在妊娠期[β0.06（95％CI 0.03，0.09）]和婴儿期[β0.04（95％CI 0.00，0.07）]有焦虑症状的母亲的孩子有更多的睡眠问题。在妊娠14周左右每天喝≥1杯酒精的母亲的孩子的睡眠问题得分高出2分[β2.55（95％CI 0.21，4.89）]，而在此期间每天吸烟≥1支香烟的母亲的孩子的睡眠问题得分高。得分高1分[β1.07（95％CI 0.10，2.03）]。相对体重减轻（δBMI-SD）的婴儿在儿童时期有较高的睡眠问题评分[β-0.32（95％CI -0.60，-0.04）]。结论我们确定了妊娠和婴儿期与儿童睡眠问题相关的几个潜在决定因素。
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