Parkinson's disease (PD) is one of the most significant medical and social burdens of our time. The prevalence of PD increases with age and the number of individuals diagnosed with PD is expected to double from 6.9 million in 2015 to 14.2 million in 2040. To date, no drugs can stop the ongoing neurodegeneration caused by PD due to its unclear and complex pathogenic mechanisms. It has been wildly recognized that both gut microbiota and neuro-immunity are involved in the pathology of PD. In this review, we intend to provide a comprehensive overview of current knowledge on how gut microbiota involved in immune-driven pathogenesis of PD, and its potential as a new target of dietary and/or therapeutic interventions for PD.

中文翻译：

---

肠道微生物群对帕金森病免疫驱动发病机制的调控

帕金森病 (PD) 是我们这个时代最严重的医疗和社会负担之一。PD 的患病率随着年龄的增长而增加，预计诊断出 PD 的人数将从 2015 年的 690 万增加到 2040 年的 1420 万。 迄今为止，由于 PD 病因不明且复杂，没有药物可以阻止其持续的神经变性。机制。众所周知，肠道微生物群和神经免疫都参与了 PD 的病理学。在这篇综述中，我们打算全面概述肠道微生物群如何参与免疫驱动的 PD 发病机制，及其作为 PD 饮食和/或治疗干预新靶点的潜力。