Alzheimer's disease (AD) is a multifactorial neurodegenerative disease which leads to progressive dysfunction of cognition, memory and learning in elderly people. Common therapeutic agents are not only inadequate to suppress the progression of AD pathogenesis but also produce deleterious side effects; hence, development of alternative therapies is required to specifically suppress complications of AD. The current review provides a commentary on conventional as well as novel therapeutic approaches with an emphasis on stem cell and nano-based therapies for improvement and management of AD pathogenesis. According to our overview of the current literature, AD is a multi-factorial disorder with various pathogenic trajectories; hence, a multifunctional strategy to create effective neuroprotective agents is required to treat this disorder.

中文翻译：

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阿尔茨海默氏病的新型治疗策略：基于细胞的治疗和纳米治疗的意义。

阿尔茨海默氏病（AD）是一种多因素神经退行性疾病，会导致老年人认知，记忆和学习的进行性功能障碍。常见的治疗剂不仅不足以抑制AD发病机理的发展，而且还会产生有害的副作用。因此，需要开发替代疗法来特异性抑制AD并发症。当前的评论提供了对常规以及新型治疗方法的评论，重点是干细胞和基于纳米的疗法，以改善和管理AD发病机制。根据我们对当前文献的概述，AD是一种具有多种病原体轨迹的多因素疾病。因此，需要一种产生有效神经保护剂的多功能策略来治疗这种疾病。