In 1988, in the first large-scale prospective study of Guillain-Barré syndrome (GBS), John Winer and colleagues collected and followed 100 patients from the London area.1 A year later, 20% of the patients were still unable to walk, and an additional 13% had died, 10% directly from the disease. The series was probably biased towards more severely affected patients. At that time only supportive treatment was available, plasma exchange was rarely used and intravenous immunoglobulin (IVIg) never. There have been many subsequent prospective studies of GBS but all have now been trumped by the International GBS Outcome Study (IGOS) which has collected more than 1800 patients.2 In an analysis of the first 1000 included patients, 8% were unable to walk and 7% had died after a year, with the prognosis being much worse in Bangladesh than in Europe/the Americas and the rest of Asia.3 It is likely that this study was also biased towards more severe disease as most patients were collected from large referral hospitals: this was confirmed in Denmark where the average severity was less in the population as a whole than in those captured by IGOS.4 In the series of Winer and colleagues, factors which predicted a worse prognosis were rapidity of onset, need for ventilation, older age and small distally evoked compound muscle action potentials.1 A Dutch study of 397 patients identified older age, more severe weakness …

中文翻译：

---

格林－巴雷综合症：回顾……向前。

1988年，约翰·温纳（John Winer）及其同事在首次进行的格林-巴利综合征（GBS）大规模大规模前瞻性研究中，对伦敦地区的100名患者进行了随访。1一年后，仍有20％的患者无法走路，另有13％的人死亡，其中10％直接死于该疾病。该系列可能偏向于受影响更严重的患者。当时只有支持治疗可用，很少使用血浆交换，并且从未使用过静脉免疫球蛋白（IVIg）。随后开展了许多有关GBS的前瞻性研究，但现在已被国际GBS结果研究（IGOS）所取代，该研究已收集了1800多名患者。2在对前1000名患者的分析中，有8％的患者无法行走和行走一年后死亡了7％，