Intake of dietary advanced glycation end products influences inflammatory markers, immune phenotypes, and antiradical capacity of healthy elderly in a little‐studied population,Food Science & Nutrition

当前位置： X-MOL 学术 › Food Sci. Nutr. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Intake of dietary advanced glycation end products influences inflammatory markers, immune phenotypes, and antiradical capacity of healthy elderly in a little‐studied population
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2020-01-10 , DOI: 10.1002/fsn3.1389
Ali Madi Almajwal ₁ , Iftikhar Alam _{1,

2} , Mahmoud Abulmeaty ₁ , Suhail Razak ₁ , Graham Pawelec _{3,

4} , Wajid Alam ₅

Affiliation

Dietary advanced glycation end products (dAGE) have profound negative effects on overall health, and their intake must be assessed. In this cross‐sectional study, we investigated dAGE intake of 337 adult participants (180/157:M/F; age range 50–73 years). Data were collected on anthropometrics, body composition, dietary intake, selected blood biochemistry, immunological parameters, and antiradical capacity (50% hemolysis time; HT₅₀). From the dietary data, dAGEs and phytochemical index (PI) were calculated. Mean BMI, % body fat (%BF), and fasting plasma glucose were all within the accepted normal range. Subjects with high dAGE intake had higher %BF, higher energy intake, and lower PI. They tended to have lower CD4/CD8 ratios and higher proportions of B cells and NK cells, but had significantly higher hs‐CRP levels and lower HT₅₀ values. Results on HT₅₀ suggested that being >60 years of age enhanced dAGE‐associated impairment of defense capacity in both those with low and high HT₅₀ compared with those <60 years of age. Thus, overall dAGE consumption was high, but elderly participants had lower dAGE intake than younger adults. Indicators of nutritional status and immunological parameters of the subjects were found to be associated with dAGE intake, suggesting a potential impact on health.

中文翻译：

在很少研究的人群中，饮食中晚期糖基化终产物的摄入会影响健康老年人的炎症标志物、免疫表型和抗自由基能力

膳食晚期糖基化终末产物 (dAGE) 对整体健康具有深远的负面影响，必须对其摄入量进行评估。在这项横断面研究中，我们调查了 337 名成年参与者（180/157：男/女；年龄范围 50-73 岁）的 dAGE 摄入量。收集有关人体测量学、身体成分、饮食摄入量、选定的血液生化、免疫学参数和抗自由基能力（50%溶血时间；HT ₅₀ ）的数据。根据饮食数据，计算 dAGE 和植物化学指数 (PI)。平均 BMI、体脂百分比 (%BF) 和空腹血糖均在可接受的正常范围内。 dAGE 摄入量高的受试者具有较高的 %BF、较高的能量摄入和较低的 PI。他们的 CD4/CD8 比率往往较低，B 细胞和 NK 细胞比例较高，但 hs-CRP 水平显着较高，HT ₅₀值较低。 HT ₅₀结果表明，与年龄 <60 岁的人相比，HT ₅₀低和高的人中，年龄 >60 岁都会增强与 dAGE 相关的防御能力受损。因此，总体 dAGE 消耗量较高，但老年参与者的 dAGE 摄入量低于年轻人。研究发现受试者的营养状况和免疫学参数指标与 dAGE 摄入量相关，这表明对健康的潜在影响。

更新日期：2020-01-10

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11