Biomimetic Networks with Enhanced Photodynamic Antimicrobial Activity from Conjugated Polythiophene/Polyisocyanide Hybrid Hydrogels.,Angewandte Chemie International Edition

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Biomimetic Networks with Enhanced Photodynamic Antimicrobial Activity from Conjugated Polythiophene/Polyisocyanide Hybrid Hydrogels.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-01-09 , DOI: 10.1002/anie.201910979
Hongbo Yuan ₁ , Yong Zhan ₁ , Alan E Rowan _{2,

3} , Chengfen Xing ₁ , Paul H J Kouwer ₂

Affiliation

Hybrid biomimetic hydrogels with enhanced reactive oxygen species (ROS)-generation efficiency under 600 nm light show high antibacterial activity. The hybrid gels are composed of helical tri(ethylene glycol)-functionalized polyisocyanides (PICs) and a conformation-sensitive conjugated polythiophene, poly(3-(3'-N,N,N-triethylammonium-1'-propyloxy)-4-methyl-2,5-thiophene chloride) (PMNT). The PIC polymer serves as a scaffold to trap and align the PMNT backbone into a highly ordered conformation, resulting in redshifted, new sharp bands in the absorption and fluorescence spectra. Similar to PIC, the hybrid closely mimics the mechanical properties of biological gels, such as collagen and fibrin, including the strain stiffening properties at low stresses. Moreover, the PMNT/PIC hybrids show much higher ROS production efficiency under red light than PMNT only, leading to an efficient photodynamic antimicrobial effect towards various pathogenic bacteria.

中文翻译：

结合的聚噻吩/多异氰酸酯杂化水凝胶具有增强的光动力抗菌活性的仿生网络。

在600 nm光下具有增强的活性氧（ROS）生成效率的混合仿生水凝胶显示出很高的抗菌活性。杂化凝胶由螺旋三（乙二醇）官能化的多异氰酸酯（PIC）和构象敏感的共轭聚噻吩，聚（3-（3'-N，N，N-三乙基铵-1'-丙氧基）-4-甲基-2,5-噻吩氯）（PMNT）。PIC聚合物用作支架，将PMNT主链捕获并排列成高度有序的构象，从而在吸收光谱和荧光光谱中产生红移的新的清晰带。与PIC相似，该杂化体紧密模拟生物凝胶（如胶原蛋白和血纤蛋白）的机械性能，包括低应力下的应变增强性能。此外，

更新日期：2020-01-10

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