Miniature probe for dual-modality photoacoustic microscopy and white-light microscopy for image guidance: A prototype toward an endoscope.,Journal of Biophotonics

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Miniature probe for dual-modality photoacoustic microscopy and white-light microscopy for image guidance: A prototype toward an endoscope.
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2020-01-13 , DOI: 10.1002/jbio.201960200
Guangyao Li ₁ , Zhanhong Ye ₁ , Siqi Liang ₁ , Sung-Liang Chen _{1,

2}

Affiliation

In this study, a novel photoacoustic microscopy (PAM) probe integrating white‐light microscopy (WLM) modality that provides guidance for PAM imaging and complementary information is implemented. One single core of an imaging fiber bundle is employed to deliver a pulsed laser for photoacoustic excitation for PAM mode, which provides high resolution with deep penetration. Meanwhile, for WLM mode, the imaging fiber bundle is used to transmit two‐dimensional superficial images. Lateral resolution of 7.2 μm for PAM is achieved. Since miniature components are used, the probe diameter is only 1.7 mm. Imaging of phantom and animals in vivo is conducted to show the imaging capability of the probe. The probe has several advantages by introducing the WLM mode, such as being able to conveniently identify regions of interest and align the focus for PAM mode. The prototype of an endoscope shows potential to facilitate clinical photoacoustic endoscopic applications.

中文翻译：

用于双模态光声显微镜和白光显微镜的微型探头，用于图像引导：内窥镜的原型。

在这项研究中，实现了一种新型的结合白光显微镜（WLM）模式的光声显微镜（PAM）探针，该探针可为PAM成像和补充信息提供指导。成像光纤束的一个单芯用于为PAM模式提供用于光声激发的脉冲激光，从而提供具有深穿透力的高分辨率。同时，对于WLM模式，成像光纤束用于传输二维表面图像。PAM的横向分辨率为7.2μm。由于使用了微型组件，因此探头直径仅为1.7 mm。进行体内幻像和动物的成像以显示探针的成像能力。该探针通过引入WLM模式具有多个优点，例如能够方便地识别感兴趣的区域并为PAM模式对齐焦点。

更新日期：2020-01-13

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