Enteroviruses, members of the Picornaviridae family, are non-enveloped and single-stranded RNA viruses responsible for several human diseases. During infection, these viruses build membrane-bound organelles, called replication organelles (ROs), where new virions are assembled. ROs are highly enriched in phosphatidylinositol 4-phosphate (PI4P) produced by the host lipid kinase PI4KB. In this issue of EMBO Reports, McPhail et al [1] characterize a complex, formed by PI4KB and the c10orf76 protein, which is involved in PI4P production. They show that this machinery is hijacked by specific enteroviruses such as coxsackievirus A10 for their replication.

中文翻译：

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又一劫持！一些肠道病毒为了自身利益而选择 c10orf76/PI4KB 复合体。


肠道病毒是小核糖核酸病毒科的成员，是一种无包膜单链 RNA 病毒，可导致多种人类疾病。在感染过程中，这些病毒会构建膜结合细胞器，称为复制细胞器（RO），在那里组装新的病毒粒子。 RO 富含由宿主脂质激酶 PI4KB 产生的磷脂酰肌醇 4-磷酸 (PI4P)。在本期 EMBO 报告中，McPhail 等人 [1] 描述了由 PI4KB 和 c10orf76 蛋白形成的复合物，该复合物参与 PI4P 的产生。他们表明，这种机器被柯萨奇病毒 A10 等特定肠道病毒劫持进行复制。