A Small Molecular Multifunctional Tool for pH Detection, Fluorescence Imaging, and Photodynamic Therapy,ACS Applied Bio Materials

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A Small Molecular Multifunctional Tool for pH Detection, Fluorescence Imaging, and Photodynamic Therapy
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-01-21 , DOI: 10.1021/acsabm.9b01080
Qingbin Zeng ₁ , Qianni Guo _{1,

2} , Yaping Yuan _{1,

2} , Xiaoxiao Zhang ₁ , Weiping Jiang _{1,

2} , Sa Xiao _{1,

2} , Bin Zhang ₁ , Xin Lou ₃ , Chaohui Ye _{1,

2} , Maili Liu _{1,

2} , Louis-S Bouchard ₄ , Xin Zhou _{1,

2}

Affiliation

A smart multitool platform for theranostics would be useful for monitoring the administration of therapies in vivo. However, the integration of multiple functions into a single small-molecule platform remains a challenge. In this study, we developed a multifunctional probe based on a small-molecule platform. The properties of this probe were investigated via hyperpolarized ¹²⁹Xe NMR/MRI, fluorescence imaging in cells and in vivo, and photodynamic therapy (PDT) in tumor mouse models. This multifunctional probe shows good pH response across a broad range of pH values. It also exhibits excellent fluorescence in vivo for mapping its biodistribution. Additionally, it produces enough ¹O₂ radicals for in vivo PDT. The combination of these functionalities into a single small-molecule platform, rather than a bulky nanoconstruct, offers unique possibilities for molecular imaging and therapy.

中文翻译：

用于 pH 检测、荧光成像和光动力治疗的小分子多功能工具

用于治疗诊断的智能多功能工具平台将有助于监测体内治疗的管理。然而，将多种功能集成到一个小分子平台中仍然是一个挑战。在这项研究中，我们开发了一种基于小分子平台的多功能探针。该探针的特性通过超极化¹²⁹ Xe NMR/MRI、细胞和体内荧光成像以及肿瘤小鼠模型中的光动力疗法 (PDT) 进行了研究。这种多功能探针在广泛的 pH 值范围内显示出良好的 pH 响应。它还在体内表现出出色的荧光，可用于绘制其生物分布图。此外，它产生足够的¹ O ₂体内 PDT 的自由基。将这些功能组合成一个小分子平台，而不是庞大的纳米结构，为分子成像和治疗提供了独特的可能性。

更新日期：2020-01-22

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