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In-Vitro Antibacterial, Antioxidant and Cytotoxic Potential of Silver Nanoparticles Synthesized Using Novel Eucalyptus tereticornis Leaves Extract
Journal of Inorganic and Organometallic Polymers and Materials ( IF 3.9 ) Pub Date : 2020-01-10 , DOI: 10.1007/s10904-020-01443-7
M. S. Kiran , Virupaxappa S. Betageri , C. R. Rajith Kumar , S. P. Vinay , M. S. Latha

In present study, silver nanoparticles (AgNPs) were synthesized using Eucalyptus tereticornis leaves extract as bioreducing agent. Prepared AgNPs were characterized and confirmed using various analytical tools such as UV–Vis spectroscopy, XRD, SEM with EDS and TEM. Crystallographic studies were carried by XRD analysis. Size, morphology was studied by SEM, TEM and elemental composition confirmed by EDS respectively. AgNPs showed significant antibacterial activity against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacterial strains. AgNPs also exhibited promising 1,1-Diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity with IC50 59.0 μg/mL. Further, cytotoxic activity performed on Michigan Cancer Foundation-7 (MCF-7) cell line proved that the prepared AgNPs have potential anticancer activity having 63.257 μg/ml 50% inhibition concentration.

中文翻译:

使用新型桉树叶片提取物合成的银纳米粒子的体外抗菌,抗氧化和细胞毒性潜力

在本研究中,以松叶提取物为生物还原剂合成了银纳米颗粒(AgNPs)。使用各种分析工具(如紫外可见光谱,XRD,带EDS的SEM和TEM)对制备的AgNP进行表征和确认。通过XRD分析进行晶体学研究。通过SEM,TEM和EDS确定的元素组成研究了尺寸,形态。AgNPs对革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌菌株具有显着的抗菌活性。AgNPs还表现出有希望的IC 50清除1,1-二苯基-2-吡啶并肼基(DPPH)自由基的活性59.0微克/毫升 此外,对密歇根州癌症基金会-7(MCF-7)细胞系进行的细胞毒性活性证明,制备的AgNP具有潜在的抗癌活性,其抑制浓度为63.257μg/ ml。
更新日期:2020-01-10
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