BACKGROUND Perimenopausal women gain weight that may alter inflammatory status, endocrine equilibrium, and the intensity of vasomotor symptoms. OBJECTIVE To measure serum levels of markers related to adiposity, inflammation/angiogenesis and digestive metabolism and correlate them with body mass index (BMI), waist-to-hip ratio (WHR), metabolic parameters and menopausal symptoms (assessed with the 10-item Cervantes Scale [CS-10]). METHODS Serum of perimenopausal women (n = 24), STRAW stages-2 and -1, was analyzed using the Bio-Plex 200 System technology to assess 30 proposed analytes. The MetS was defined by the American Heart Association criteria and women were divided as: normal BMI (NBMI), excessive BMI (EBMI), and EBMI with MetS (EBMI-MetS). RESULTS Weight, BMI, abdominal circumference, WHR, systolic blood pressure, glucose and triglyceride levels were significantly higher and high-density lipoprotein cholesterol (HDL-C) was lower in EBMI-MetS women compared to NBMI ones. Insulin, C-peptide, resistin, adipsin, GIP, leptin, IL-6, FGF21 and PAI-1 levels were significantly higher and ghrelin and IGFBP-1 lower in EBMI-MetS women as compared to NBMI ones. Spearman's correlation of pooled data showed a significant positive correlation between abdominal perimeter and WHR and C-peptide, insulin, adipsin, resistin, leptin, PAI-1 and FGF21 and a negative correlation with IGFBP-1 levels. Total CS-10 scores and hot flush intensity did not differ between studied groups, yet positively correlated with anthropometric values but not with studied analytes. CONCLUSION Perimenopausal women with EBMI and the MetS showed an altered metabolic profile, but no differences in menopausal symptoms which also did not correlate with changes in studied biomarkers.

中文翻译：

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围绝经期，体内脂肪，新陈代谢和更年期症状与肥胖，炎症和消化代谢的血清标志物有关。

背景技术围绝经期妇女的体重增加，可能会改变炎症状态，内分泌平衡和血管舒缩症状的强度。目的测量与肥胖，炎症/血管生成和消化代谢有关的标志物的血清水平，并将其与体重指数（BMI），腰臀比（WHR），代谢参数和更年期症状相关联（按10个项目评估）塞万提斯量表[CS-10]。方法采用Bio-Plex 200系统技术对STRAW-2和-1期的绝经后妇女血清（n = 24）进行分析，以评估30种建议的分析物。MetS由美国心脏协会标准定义，女性分为：正常BMI（NBMI），过量BMI（EBMI）和合并MetS的EBMI（EBMI-MetS）。结果体重，BMI，腹围，WHR，收缩压，与NBMI相比，EBMI-MetS妇女的葡萄糖和甘油三酸酯水平显着较高，而高密度脂蛋白胆固醇（HDL-C）较低。与NBMI相比，EBMI-MetS妇女的胰岛素，C肽，抵抗素，脂肪酶，GIP，瘦素，IL-6，FGF21和PAI-1水平显着升高，而ghrelin和IGFBP-1降低。Spearman的汇总数据相关性显示，腹围与WHR和C肽，胰岛素，脂肪，抵抗素，瘦素，PAI-1和FGF21之间呈显着正相关，与IGFBP-1水平呈负相关。研究组之间的CS-10总得分和潮热强度没有差异，但与人体测量值呈正相关，但与研究分析物没有正相关。结论围绝经期妇女EBMI和MetS表现出新陈代谢改变，