Antiepileptic drug (Preg) and neurotransmitters (Gpn, Gly, Asp, Glu, Ser, GABA and Ade) were used to synthesis a series of ternary Cu²⁺ complexes. Surface morphology and chemical composition of the complexes were using studied SEM and EDX spectra. Purity, molecular weight and formulae of the complexes were determined from GC–MS spectra and elemental analysis. XRD data and N-Treor implemented in Expo2014 computer program reveal monoclinic crystal system with space group P1 2/c 1 and P 1 21 1 of the complexes. IR spectra exhibited that Preg, Gpn and GABA coordinated to the Cu²⁺ as monodentate ligand through COOH whereas the amino acids bonded through the –NH₂, COO– groups. UV–Vis spectra and magnetic moment values indicated pseudo tetrahedral stereochemistry. ESR spectra showed that the complexes have isotropic and axial structures with d_x²_-y² ground state. TGA, DTG and DTA confirm the suggested structure and mechanism for thermal decomposition was suggested. Kinetic and thermodynamic parameters were calculated using Coats-Redfern equation. The complexes [Cu(Preg)(Ser)Cl] and [Cu(Preg)(Ade)Cl₂] showed greater anticonvulsant activity compared against PTZ-induced seizures in male Albino mice. Recorded latency time for the complexes [Cu(Preg)(Ser)Cl] and [Cu(Preg)(GABA)(OH)Cl].2H₂O was longer than that recorded with Preg indicating higher anticonvulsant effect.

抗癫痫药（Preg）和神经递质（Gpn，Gly，Asp，Glu，Ser，GABA和Ade）用于合成一系列三价Cu ²⁺复合物。使用研究的SEM和EDX光谱对配合物的表面形态和化学组成进行了研究。通过GC-MS光谱和元素分析确定配合物的纯度，分子量和分子式。在Expo2014计算机程序中实现的XRD数据和N-Treor揭示了具有P1 2 / c 1和P 1 21 1空间群的单斜晶体系统。红外光谱表明，Preg，Gpn和GABA通过COOH与Cu ²⁺配位为单齿配体，而氨基酸通过–NH ₂键合，COO–组。UV-Vis光谱和磁矩值表示伪四面体立体化学。ESR谱表明，该配合物具有各向同性和轴向结构，基态为d _x ² _-y ²。TGA，DTG和DTA证实了建议的热分解结构和机理。使用Coats-Redfern方程计算动力学和热力学参数。复合物[Cu（Preg）（Ser）Cl]和[Cu（Preg）（Ade）Cl ₂ ]与雄性白化病小鼠的PTZ诱发的癫痫发作相比显示出更高的抗惊厥活性。记录的复合物[Cu（Preg）（Ser）Cl]和[Cu（Preg）（GABA）（OH）Cl] .2H ₂ O的潜伏时间长于Preg记录的潜伏时间，表明较高的抗惊厥作用。