For twenty years, ion channels have been studied in cancer progression. Several information have been collected about their involvement in cancer cellular processes like cell proliferation, motility and their participation in tumour progression using in-vivo models. Tumour microenvironment is currently the focus of many researches and the highlighting of the relationship between cancer cells and surrounding elements, is expanding. One of the major physic-chemical parameter involved in tumour progression is the hypoxia conditions observed in solid cancer. Due to their position on the cell membrane, ion channels are good candidates to transduce or to be modulated by environmental modifications. Until now, few reports have been interested in the modification of ion channel activities or expression in this context, compared to other pathological situations such as ischemia reperfusion. The aim of our review is to summarize the current knowledge about the calcium and potassium channels properties in the context of hypoxia in tumours. This review could pave the way to orientate new studies around this exciting field to obtain new potential therapeutic approaches.

中文翻译：

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Ca2 +和K +通道在暴露于低氧肿瘤微环境的癌细胞中的作用。

二十年来，一直在研究癌症发展过程中的离子通道。已使用体内模型收集了有关它们参与癌细胞增殖过程（例如细胞增殖，运动性以及它们参与肿瘤进展）的一些信息。肿瘤微环境目前是许多研究的重点，并且对癌细胞与周围元素之间关系的强调也在不断扩大。肿瘤进展中涉及的主要物理化学参数之一是在实体癌中观察到的缺氧状况。由于其在细胞膜上的位置，离子通道是转导或通过环境修饰调节的良好候选者。到目前为止，在这种情况下，鲜有报道对离子通道活性或表达的修饰感兴趣，与其他病理情况（例如缺血再灌注）相比。我们的审查的目的是总结在肿瘤缺氧的背景下有关钙和钾通道特性的当前知识。这项综述可以为围绕这一令人兴奋的领域的新研究铺平道路，以获得新的潜在治疗方法。